Comparison of Oral Prednisone and Topical Fluticasone in the Treatment of Eosinophilic Esophagitis: A Randomized Trial in Children  Elizabeth T. Schaefer, Joseph F. Fitzgerald, Jean P. Molleston, Joseph M. Croffie, Marian D. Pfefferkorn, Mark R. Corkins, Joel D. Lim, Steven J. Steiner, Sandeep K. Gupta  Clinical Gastroenterology and Hepatology  Volume 6, Issue 2, Pages 165-173 (February 2008) DOI: 10.1016/j.cgh.2007.11.008 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Flow diagram of study participants. aSee Figure 2A. bSee Figure 2B. Clinical Gastroenterology and Hepatology 2008 6, 165-173DOI: (10.1016/j.cgh.2007.11.008) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 (A) Flow diagram of subjects randomized to P. aNoncompliance with medication, n = 4; patient/family decision, n = 2; lost to follow-up evaluation, n = 1; adverse effect, n = 1 (increased appetite and abdominal pain). bBoth exited because of adverse effects, n = 2 (cushingoid, acne, behavioral changes). (B) Flow diagram of subjects randomized to F. aNoncompliance with medication, n = 2; patient/family decision, n = 2. bPersistence of symptoms, n = 1; asymptomatic, but no histologic improvement, n = 1. Clinical Gastroenterology and Hepatology 2008 6, 165-173DOI: (10.1016/j.cgh.2007.11.008) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Histology images of the distal esophagus at the (A) time of diagnosis and (B) after 4 weeks of F demonstrate basal cell hyperplasia comprising 75% of the epithelial thickness and eosinophil counts numbering 30 eos/hpf (40× objective, total 400× magnification), and normalization of epithelium after treatment (20× objective, total 200× magnification), respectively. Clinical Gastroenterology and Hepatology 2008 6, 165-173DOI: (10.1016/j.cgh.2007.11.008) Copyright © 2008 AGA Institute Terms and Conditions

Figure 4 Kaplan–Meier curve showing proportion of symptom-free patients at each visit. Clinical Gastroenterology and Hepatology 2008 6, 165-173DOI: (10.1016/j.cgh.2007.11.008) Copyright © 2008 AGA Institute Terms and Conditions