Serum ferritin and transferrin levels as serologic markers of methylene diphenyl diisocyanate–induced occupational asthma Gyu-Young Hur, MD, PhD, Gil-Soon.

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Presentation transcript:

Serum ferritin and transferrin levels as serologic markers of methylene diphenyl diisocyanate–induced occupational asthma Gyu-Young Hur, MD, PhD, Gil-Soon Choi, MD, Seung-Soo Sheen, MD, PhD, Hyun-Young Lee, MS, Han-Jung Park, MD, Sung-Jin Choi, MD, Young-Min Ye, MD, Hae-Sim Park, MD, PhD Journal of Allergy and Clinical Immunology Volume 122, Issue 4, Pages 774-780 (October 2008) DOI: 10.1016/j.jaci.2008.07.034 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 2-DE separation of BALF proteins from AECs (A) and patients with MDI-OA (B). The proteins identified by MALDI-TOF MS (arrows) are marked by their spot numbers. Arrows indicate the spots corresponding to ferritin (8) and transferrin (1). Journal of Allergy and Clinical Immunology 2008 122, 774-780DOI: (10.1016/j.jaci.2008.07.034) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Comparison of the serum concentrations of log ferritin (A) and log transferrin (B) in subjects with MDI-OA/EB, AECs, and NCs. ∗All data are adjusted by age and sex. Dotted line indicates the mean of each value. Journal of Allergy and Clinical Immunology 2008 122, 774-780DOI: (10.1016/j.jaci.2008.07.034) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 ROC curves for the serum levels of ferritin (A) and transferrin (B), as well as the combined value (C) used to determine the optimal cutoffs for MDI-OA. Arrows indicate the optimal value for ferritin, transferrin, and the combined value (ferritin ≤ 69.84 ng/mL and transferrin ≥ 2.48 μg/mL). Gray regions represent the sensitivity range (60-100) and specificity range (50-100). Journal of Allergy and Clinical Immunology 2008 122, 774-780DOI: (10.1016/j.jaci.2008.07.034) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions