IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent and Fas- Supported Apoptosis of Alloreactive CD4+ T Cells and Inhibit Graft-Versus-Host.

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IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent and Fas- Supported Apoptosis of Alloreactive CD4+ T Cells and Inhibit Graft-Versus-Host Disease  Elizabeth Stenger, MD, Brian Rosborough, PhD, Lisa Mathews, Hui Hui Ma, MD PhD, Markus Y. Mapara, MD, PhD, Angus W. Thomson, PhD, Heth Turnquist, PhD  Biology of Blood and Marrow Transplantation  Volume 20, Issue 2, Pages S281-S283 (February 2014) DOI: 10.1016/j.bbmt.2013.12.474 Copyright © 2014 Terms and Conditions

*denotes p<0.05 Figure 3. Autologous IL-12hi RAPA-DC significantly prolong survival from acute GVHD. Biology of Blood and Marrow Transplantation 2014 20, S281-S283DOI: (10.1016/j.bbmt.2013.12.474) Copyright © 2014 Terms and Conditions

*denotes p<0.05 compared to untreated GVHD 1Median survival Figure 2. Apoptosis induced by IL-12hi RAPA-DC is dependent on T cell but not DC responses to IFN-γ and on IL-12 expression. Biology of Blood and Marrow Transplantation 2014 20, S281-S283DOI: (10.1016/j.bbmt.2013.12.474) Copyright © 2014 Terms and Conditions