Jay Kumar Singh, William E. Balch  Developmental Cell 

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Proteostatic Hotspots in Amyloid Fibrils Protect Us from Neurodegeneration  Jay Kumar Singh, William E. Balch  Developmental Cell  Volume 32, Issue 6, Pages 659-660 (March 2015) DOI: 10.1016/j.devcel.2015.03.009 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Proteostatic Hotspot Control of Native and Pathogenic Amyloid Illustrated is the impact of designer amyloid chaperones (green, blue pentamers) on proteostatic hotspots (red stars) found in polymer fibrils assembled from monomers (black spheres) catalytically nucleating toxic oligomer formation. Therapeutic management of proteostatic hotspots triggering dementia may be treatable by hotspot-targeted therapeutics (orange chevrons). Developmental Cell 2015 32, 659-660DOI: (10.1016/j.devcel.2015.03.009) Copyright © 2015 Elsevier Inc. Terms and Conditions

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