Urocortin and corticotrophin-releasing hormone receptor type 2 mRNA are highly expressed in deep infiltrating endometriotic lesions Patrizia Carrarelli,

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Presentation transcript:

Urocortin and corticotrophin-releasing hormone receptor type 2 mRNA are highly expressed in deep infiltrating endometriotic lesions Patrizia Carrarelli, Alice Luddi, Lucia Funghi, Felice Arcuri, Frederic Batteux, Cynthia Dela Cruz, Claudia Tosti, Fernando M. Reis, Charles Chapron, Felice Petraglia Reproductive BioMedicine Online Volume 33, Issue 4, Pages 476-483 (October 2016) DOI: 10.1016/j.rbmo.2016.07.009 Copyright © 2016 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Corticotrophin-releasing hormone (CRH), Ucn, Ucn2, CRH-R1 and CRH-R2 mRNAs expression in eutopic endometrium of endometriosis (ENDO), in deep infiltrating lesions (DIE) and in endometrioma (OMA). Fold change (y axis, mean ± SD) represents mRNA expression normalized to hypoxanthine phosphoribosyl transferase (n = 48 [ENDO]; n = 22 [OMA]; n = 26 [DIE]; *P < 0.05, **P < 0.01, ***P < 0.001). Reproductive BioMedicine Online 2016 33, 476-483DOI: (10.1016/j.rbmo.2016.07.009) Copyright © 2016 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 (a–e) Immunohistochemical localization of corticotrophin-releasing hormone and (f–j) Ucn in (a,b,f,g) deep infiltrating endometriotic lesions (DIE) and (c,h) eutopic endometrium (Endo). Specific staining is shown in the basal (black arrows) and apical (white arrowheads) sides of glandular epithelium (GE) and in endometrial stromal cells (S, black arrowheads) and macrophages (white arrow). GL, glandular lumen; V, blood vessel. a, b, c, f, h,i scale bar = 40 µm; b, g scale bar = 20 µm. Negative controls for CRH and Ucn are shown respectively in (d) and (i). The scatter plots summarize the immunostaining scores with the respective medians and quartiles for (e) CRH and (j) Ucn (n = 6; *P < 0.05 [Mann–Whitney test]). Reproductive BioMedicine Online 2016 33, 476-483DOI: (10.1016/j.rbmo.2016.07.009) Copyright © 2016 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 PLA2G2A and COX2 mRNAs expression in eutopic endometrium of endometriosis (ENDO), in deep infiltrating lesions (DIE) and in ovarian endometrioma (OMA). Fold change (y axis) represents mRNA expression normalized to hypoxanthine phosphoribosyl transferase (n = 48 [ENDO]; n = 22 [OMA]; n = 26 [DIE]; *P < 0.05, **P < 0.01, ***P < 0.001). Reproductive BioMedicine Online 2016 33, 476-483DOI: (10.1016/j.rbmo.2016.07.009) Copyright © 2016 Reproductive Healthcare Ltd. Terms and Conditions

Figure 4 Effects of Ucn at 10−6, 10−7 or 10−8 M (Ucn-6, Ucn-7 and Ucn-8) and its antagonists astressin (Ast) and astressin 2B (Ast2B) (when combined with Ucn at 10−7M) on COX2 mRNA expression in human embryonic stem cells from healthy women. Fold change (y axis, mean ± SD) represents mRNA expression normalized to hypoxanthine phosphoribosyl transferase (n = 3; **P < 0.01). Reproductive BioMedicine Online 2016 33, 476-483DOI: (10.1016/j.rbmo.2016.07.009) Copyright © 2016 Reproductive Healthcare Ltd. Terms and Conditions