T Helper 17 Cells Get the NOD Daniel B. Stetson, Ruslan Medzhitov  Immunity  Volume 27, Issue 4, Pages 546-548 (October 2007) DOI: 10.1016/j.immuni.2007.10.005 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 NOD2 Activates Th17 Effector Function in Human Memory CD4+ T Cells The pathway defined by van Beelen et al. (2007) reveals that NOD2 activation by MDP results in potent production of IL-1 and IL-23, which prime memory CD4+ T cells to produce IL-17. Important issues that remain to be explored include a mechanistic connection between NOD2 and caspase-1, possibly through the CARDs of these two proteins, and the signaling pathway that links NOD2 activation to transcription of IL-23 p19. It will also be interesting to determine whether NOD2 stimulation also activates a regulatory pathway to limit Th17 effector function. Immunity 2007 27, 546-548DOI: (10.1016/j.immuni.2007.10.005) Copyright © 2007 Elsevier Inc. Terms and Conditions