Figure 3 Classical complement pathway activity and disease severity (A) Association between high innate classical pathway (CP) activity and degree of muscle.

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Figure 3 Classical complement pathway activity and disease severity (A) Association between high innate classical pathway (CP) activity and degree of muscle weakness and axon loss. Classical complement pathway activity and disease severity (A) Association between high innate classical pathway (CP) activity and degree of muscle weakness and axon loss. Innate CP activity was higher in patients with mild (p = 0.006), moderate (p = 0.02), and severe weakness (p = 0.003) compared with those with minor weakness. Axon loss was also more pronounced in patients with higher innate CP activity (mild p = 0.17, moderate p = 0.03, severe p = 0.07). (B) Association between activation of the complement system by IgM anti-GM1 antibodies and degree of muscle weakness and axon loss. Anti-GM1 IgM complement-activating capacity, defined by the deposition of complement component C3, was significantly higher in the patients with severe weakness (p = 0.03) and axonal loss (p = 0.01) compared with those with minor weakness or axon loss. Data were analyzed in a multivariate model with sex, conduction block, age at onset, number of years untreated, and IgG concentration included as covariates. Data are presented as mean with SEM. *p < 0.05. OD = optical density. Lotte Vlam et al. Neurol Neuroimmunol Neuroinflamm 2015;2:e119 © 2015 American Academy of Neurology