This Month in Gastroenterology Jan Tack, John M. Carethers  Gastroenterology  Volume 136, Issue 7, Pages 2033-2036 (June 2009) DOI: 10.1053/j.gastro.2009.04.034 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 Proportion of patients in clinical remission at 3 and 6 weeks, shown as intention-to-treat (ITT) and per protocol (PP) analyses. Gastroenterology 2009 136, 2033-2036DOI: (10.1053/j.gastro.2009.04.034) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 Kaplan–Meier analysis of time to carcinoma for patients by (A) routine cytology result and (B) FISH result. Gastroenterology 2009 136, 2033-2036DOI: (10.1053/j.gastro.2009.04.034) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 Proposed model of negative feedback signaling in the intestinal epithelial crypt. Indian hedgehog (Ihh) secreted by differentiated cells acts on the myofibroblasts which secrete factors such as bone morphogenetic proteins (Bmp) that subsequently negatively regulate precursor cells at the base of the crypt. Gastroenterology 2009 136, 2033-2036DOI: (10.1053/j.gastro.2009.04.034) Copyright © 2009 AGA Institute Terms and Conditions

Figure 4 Efficient deletion of Dicer1 in young Albumin-Cre;Dicer1loxP/loxP mouse liver and repopulation with Dicer1-expressing hepatocytes. (A) Gross morphology of control and Albumin-Cre;Dicer1loxP/loxP mouse livers at 3, 6, and 12 weeks after birth. At 3 weeks, the Albumin-Cre;Dicer1loxP/loxP mouse liver was pale compared with the control. At 6 weeks, the Albumin-Cre;Dicer1loxP/loxP liver had become yellowish, with the appearance of normal-colored spots. The normal-colored areas had expanded at 12 weeks. (B) Quantitative polymerase chain reaction analysis of Cre transgene expression in Albumin-Cre;Dicer1loxP/loxP mouse liver. (C) Quantitative polymerase chain reaction analysis of Dicer1 expression. Dicer1 expression recovered with age. Gastroenterology 2009 136, 2033-2036DOI: (10.1053/j.gastro.2009.04.034) Copyright © 2009 AGA Institute Terms and Conditions