A New Artificial Placenta with a Centrifugal Pump: Long-Term Total Extrauterine Support of Goat Fetuses Masahiro Sakata, MD, Katsuya Hisano, MD, Masayoshi.

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Presentation transcript:

A New Artificial Placenta with a Centrifugal Pump: Long-Term Total Extrauterine Support of Goat Fetuses Masahiro Sakata, MD, Katsuya Hisano, MD, Masayoshi Okada, MD, Masao Yasufuku, MD The Journal of Thoracic and Cardiovascular Surgery Volume 115, Issue 5, Pages 1023-1031 (May 1998) DOI: 10.1016/S0022-5223(98)70401-5 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 The system of the fetal AV-ECMO. The circuit consists of a centrifugal pump (HPM-15, Nikkiso Ltd.), a membrane oxygenator (Menox 2000 Kurare), an in-line electromagnetic blood flowmeter (MFV 1100, Nihon Kohden Co.), and an optical fluorescence blood gas monitor (CDI 300, Cardiovascular Devices Inc.). Ao, Aorta; PA, pulmonary artery; UA, umbilical artery; UV, umbilical vein; DA, ductus arteriosus; DV, ductus venosus; IVC, inferior vena cava; SVC, superior vena cava; RV, right ventricle; LV, left ventricle; LA, left atrium; RA, right atrium; FO, foramen ovale. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 1023-1031DOI: (10.1016/S0022-5223(98)70401-5) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Interrelationship between carotid arterial pressure and pump flow rate. The pump flow featured a pulsatile high flow and was matched in pulsation and shape with the cardiac cycle. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 1023-1031DOI: (10.1016/S0022-5223(98)70401-5) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Echocardiographic findings in the ductus arteriosus during total extrauterine support. A, The ductus arteriosus was wide open. Direction of ductal blood flow is right to left shunt. Peak velocity of ductal blood flow is 1.8 msec. Pump flow, 150 ml/min/kg at 800 rpm; heart rate, 134/min; blood pressure, 75/42(54) mm Hg. Ao, Aorta; DA, ductus arteriosus; PA, pulmonary artery. B, The ductus arteriosus was wide open. Direction of ductal blood flow is right to left shunt. Peak velocity of ductal blood flow is 1.8 msec. Pump flow, 178 ml/min/kg at 1000 rpm; heart rate, 146/min; blood pressure, 80/47(58) mm Hg. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 1023-1031DOI: (10.1016/S0022-5223(98)70401-5) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 4 Physiologic and biochemical parameters monitored during a 237-hour perfusion (case 2). The Journal of Thoracic and Cardiovascular Surgery 1998 115, 1023-1031DOI: (10.1016/S0022-5223(98)70401-5) Copyright © 1998 Mosby, Inc. Terms and Conditions