A Clock Ticks in Pancreatic β Cells

Slides:

Advertisements

Similar presentations

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

Advertisements

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

Xenobiotic metabolism in the fourth dimension: PARtners in time

Volume 14, Issue 2, Pages (August 2011)

Ghrelin—a new player in glucose homeostasis?

NCOA5, IL-6, Type 2 Diabetes, and HCC: The Deadly Quartet

Insulin Release: Shedding Light on a Complex Matter

Novel SIRT1 Mutation Linked to Autoimmune Diabetes in Humans

Volume 17, Issue 5, Pages (May 2013)

ERRγ—A New Player in β Cell Maturation

Volume 153, Issue 6, Pages (June 2013)

Rashmi B. Prasad, Leif Groop Cell Metabolism

A Time to Divide: Does the Circadian Clock Control Cell Cycle?

Pancreatic β cells: Responding to the matrix

Stopping the Clock with MYC

Serotonin and the Orchestration of Energy Balance

Volume 23, Issue 3, Pages (March 2016)

Safia Costes, Peter C. Butler Cell Metabolism

Metabolic Regulation of Stem Cell Behavior and Implications for Aging

TCF7L2 and Diabetes: A Tale of Two Tissues, and of Two Species

High T Gives β Cells a Boost

Jelena Kolic, James D. Johnson Cell Metabolism

NCOA5, IL-6, Type 2 Diabetes, and HCC: The Deadly Quartet

Insulin biosynthesis: The IREny of it all

Volume 26, Issue 1, Pages 6-7 (July 2017)

The CAMplexities of Central Ghrelin

Life Is Short, if Sweet Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

Juleen R. Zierath, Harriet Wallberg-Henriksson Cell Metabolism

Autophagy: A Sweet Process in Diabetes

[Br]eaking FAt Cell Volume 159, Issue 2, Pages (October 2014)

IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

Branching Out for Detection of Type 2 Diabetes

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism David Carling, Benoit Viollet Cell Metabolism

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Volume 11, Issue 3, Pages (March 2010)

Lung Cancer Resets the Liver’s Metabolic Clock

Volume 16, Issue 5, Pages (November 2012)

Dietary Carbohydrates Impair Healthspan and Promote Mortality

Bryan Krock, Nicolas Skuli, M. Celeste Simon Cell Metabolism

Targeting Time in Metabolic Therapeutics

p38δ and PKD1: Kinase Switches for Insulin Secretion

Do Cancer Cells Care If Their Host Is Hungry?

John D. Gordan, Craig B. Thompson, M. Celeste Simon Cancer Cell

Fly-let Biology and the High Protein/Low Carb Diet

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

Exercise Controls Non-Coding RNAs

Hold the Door: Role of the Gut Barrier in Diabetes

Volume 14, Issue 2, Pages (August 2011)

Cellular iron: Ferroportin is the only way out

Anna B. Osipovich, Mark A. Magnuson Cell Stem Cell

An IRKO in the Podo: Impaired Insulin Signaling in Podocytes and the Pathogenesis of Diabetic Nephropathy Susan B. Gurley, Thomas M. Coffman Cell Metabolism

Ann Marie Schmidt, Kathryn J. Moore Cell Metabolism

Treating Diabetes by Blocking a Vascular Growth Factor

Volume 1, Issue 1, Pages 9-14 (January 2005)

Xenobiotic metabolism in the fourth dimension: PARtners in time

Deciphering Pancreatic Islet β Cell and α Cell Maturation Pathways and Characteristic Features at the Single-Cell Level Wei-Lin Qiu, Yu-Wei Zhang, Ye.

Collecting new targets in MODY

Macrophage Metabolism Shapes Angiogenesis in Tumors

Should I Stay or Should I Go: A Clash of α-Cell Identity

The Insulin Receptor Talks to Glucagon?

Volume 19, Issue 4, Pages (April 2014)

Presentation transcript:

A Clock Ticks in Pancreatic β Cells Jun Yoshino, Shin-ichiro Imai Cell Metabolism Volume 12, Issue 2, Pages 107-108 (August 2010) DOI: 10.1016/j.cmet.2010.07.006 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Maintenance of Glucose Homeostasis by the Pancreatic Core Clock Machinery A scheme of CLOCK/BMAL1-mediated regulation of β cell function is shown. The core clock mechanism mediated by CLOCK and BMAL1 regulates insulin secretion, likely at the step of insulin granule exocytosis, and proliferation in pancreatic islets. Lifestyle, dietary conditions, and other oscillators might modulate the CLOCK/BMAL1-mediated core clock mechanism in β cells. The disruption of this mechanism leads to type 2 diabetes due to the defect in rhythmic gene expression and hypoinsulinemia. Cell Metabolism 2010 12, 107-108DOI: (10.1016/j.cmet.2010.07.006) Copyright © 2010 Elsevier Inc. Terms and Conditions