Delayed Onset of Hemolytic Anemia in CBA-Pk-1slc/Pk-1slc Mice With a Point Mutation of the Gene Encoding Red Blood Cell Type Pyruvate Kinase by Kumiko.

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Delayed Onset of Hemolytic Anemia in CBA-Pk-1slc/Pk-1slc Mice With a Point Mutation of the Gene Encoding Red Blood Cell Type Pyruvate Kinase by Kumiko Tsujino, Hitoshi Kanno, Koji Hashimoto, Hisaichi Fujii, Tomoko Jippo, Eiichi Morii, Young-Mi Lee, Hidekazu Asai, Shiro Miwa, and Yukihiko Kitamura Blood Volume 91(6):2169-2174 March 15, 1998 ©1998 by American Society of Hematology

Number of RBCs and proportion of reticulocytes in CBA-+/+ (○) and -Pk-1slc/Pk-1slc (•) mice on various days after birth. Number of RBCs and proportion of reticulocytes in CBA-+/+ (○) and -Pk-1slc/Pk-1slc (•) mice on various days after birth. Each point represents the mean of ten mice. Bars are the standard error. In some points the standard error was too small to be shown by bars. Kumiko Tsujino et al. Blood 1998;91:2169-2174 ©1998 by American Society of Hematology

The effect of ages of RBC donors on the elimination of 51Cr-labeled RBCs. RBCs were collected from CBA-+/+ (○) and -Pk-1 slc /Pk-1 slc (•) mice of various ages, labeled, and injected into 90-day-old CBA-+/+ mice. The effect of ages of RBC donors on the elimination of 51Cr-labeled RBCs. RBCs were collected from CBA-+/+ (○) and -Pk-1 slc /Pk-1 slc (•) mice of various ages, labeled, and injected into 90-day-old CBA-+/+ mice. The radioactivity retained in RBCs was measured at various times after the transfusion and the percentage was plotted semi-logarithmically. Each point represents the mean of eight mice. In all points the standard error was too small to be shown by bars. Kumiko Tsujino et al. Blood 1998;91:2169-2174 ©1998 by American Society of Hematology

PAGE and staining for PK activity in extracts of fetal livers or RBCs PAGE and staining for PK activity in extracts of fetal livers or RBCs. Fetal livers were obtained from 16-day embryos of CBA-+/+ or -Pk-1slc/Pk-1slc mice; RBCs from 1-day-old and 7-day-old CBA-+/+ or -Pk-1slc/Pk-1slc mice. PAGE and staining for PK activity in extracts of fetal livers or RBCs. Fetal livers were obtained from 16-day embryos of CBA-+/+ or -Pk-1slc/Pk-1slc mice; RBCs from 1-day-old and 7-day-old CBA-+/+ or -Pk-1slc/Pk-1slc mice. M2, M2-PK; R/L, R- or L-PK. Kumiko Tsujino et al. Blood 1998;91:2169-2174 ©1998 by American Society of Hematology