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Rhodiola Rosea Director, Depression Clinical and Research Program David Mischoulon, MD, PhD Director, Depression Clinical and Research Program Massachusetts General Hospital Professor of Psychiatry Harvard Medical School

Grows at high altitudes in mountainous regions of Europe and Asia Rhodiola Rosea Grows at high altitudes in mountainous regions of Europe and Asia https://www.superfoodly.com/wp-content/uploads/2017/01/rhodiola-rosea.jpg

Functions as an Adaptogen Increases the body’s resistance to chemical, biological, and physical stressors Stimulates the nervous system Alleviating fatigue, stress, depression, and sexual dysfunction Iovieno, N. et al. (2011). Second-tier natural antidepressants: review and critique. Journal of Affective Disorders, 130(3), 343–357.

Studies on Rhodiola 4 controlled clinical trials Support efficacy for: Depression Anxiety Cognition Dose: 100 - 680 mg / day Hung, S. K. et al. (2011). The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 18(4), 235–244.

Active Ingredients The adaptogenic chemicals Rosavin Tyrosol Antioxidants e.g. flavonoids Monoamine modulation activity Antidepressant and antianxiety benefits MAO A and B inhibition Opioid-like effects Rosavin picture https://upload.wikimedia.org/wikipedia/commons/thumb/0/01/Rosavin.png/330px-Rosavin.png Tyrosol https://upload.wikimedia.org/wikipedia/commons/thumb/1/1a/Tyrosol.svg/330px-Tyrosol.svg.png Hung, S. K. et al. (2011). The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 18(4), 235–244.

Safety Safe and well tolerated Side effects: uncommon and mild Allergic reactions No safety data in Irritability Pregnancy Insomnia Caution Cycling in bipolar Fatigue (high doses) Vivid dreams Iovieno, N. et al. (2011). Second-tier natural antidepressants: review and critique. Journal of Affective Disorders, 130(3), 343–357.   Maniscalco, I. (2015). [The interaction of Rhodiola rosea and antidepressants. A case report]. Neuropsychiatrie: Klinik, Diagnostik, Therapie Und Rehabilitation: Organ Der Gesellschaft Osterreichischer Nervenarzte Und Psychiater, 29(1), 36–38.

Taken on empty stomach 30 minutes before meals Early in the day

Interactions RHODIOLA TCA side effects TCAs One case: mild serotonin syndrome when combined with paroxetine Be careful with this combination -Iovieno, N. et al. (2011). Second-tier natural antidepressants: review and critique. Journal of Affective Disorders, 130(3), 343–357.   - Maniscalco, I. (2015). [The interaction of Rhodiola rosea and antidepressants. A case report]. Neuropsychiatrie: Klinik, Diagnostik, Therapie Und Rehabilitation: Organ Der Gesellschaft Osterreichischer Nervenarzte Und Psychiater, 29(1), 36–38.

Key Points Rhodiola functions as an adaptogen that stimulates the body’s healing mechanisms. Rhodiola is best suited for mood disorders characterized by fatigue, stress and sexual dysfunction. Risk of adverse reactions occurring when combined with serotonin reuptake inhibitors.

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