Yusuf Talha Tamer, Erdal Toprak Molecular Cell

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On the Race to Starvation: How Do Bacteria Survive High Doses of Antibiotics? Yusuf Talha Tamer, Erdal Toprak Molecular Cell Volume 68, Issue 6, Pages 1019-1021 (December 2017) DOI: 10.1016/j.molcel.2017.12.004 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Pathogenic Bacteria Develop Immunity to Antibiotic Molecules Once They Consume Nutrients and Enter Stationary Growth Phase Bacteria grown in vitro follow a typical growth cycle: lag, log (exponential), and stationary phases. Cells that are in the lag or log phase are sensitive to antibiotics (green cells), and they gradually switch to an antibiotic-insensitive (red cells) phenotype as cell density increases. Persistent cells in the stationary phase can be re-sensitized to antibiotics if glucose and terminal electron acceptors, such as fumarate, are provided. Molecular Cell 2017 68, 1019-1021DOI: (10.1016/j.molcel.2017.12.004) Copyright © 2017 Elsevier Inc. Terms and Conditions