Volume 56, Issue 3, Pages (September 1999)

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Presentation transcript:

Volume 56, Issue 3, Pages 1113-1119 (September 1999) Factors determining the percentage of hypochromic red blood cells in hemodialysis patients Christophe Bovy, M.D., Chantal Tsobo, Linda Crapanzano, Georges Rorive, Yves Beguin, Adelin Albert, Jean-Michel Paulus Kidney International Volume 56, Issue 3, Pages 1113-1119 (September 1999) DOI: 10.1046/j.1523-1755.1999.00627.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Cell by cell determination of hemoglobin (Hb) concentration (abscissa) and red blood cell (RBC) volume (ordinate). Horizontal and vertical bars delineate regions with hypochromic (<28 g/dl), hyperchromic (> 42g/dl), microcytic (<60 fl), and macrocytic (>120 fl) RBC. %HYPO was 0.9% (A) and 24.7% (B). Kidney International 1999 56, 1113-1119DOI: (10.1046/j.1523-1755.1999.00627.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Relationship between %HYPO and logit %HYPO. Kidney International 1999 56, 1113-1119DOI: (10.1046/j.1523-1755.1999.00627.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Correlation studies between %HYPO and iron parameters [serum iron (SI), transferrin (Tf) saturation, soluble transferrin receptor (sTfR), ferritin], C-reactive protein (CRP), and erythropoietin (EPO) administered. To normalize variables as explained in the Methods section, sTfR, ferritin, CRP, and EPO have been displayed on a log scale on the abscissa. The ordinates have been expressed as both %HYPO on a logit scale (left) and logit %HYPO on a linear scale (right) to show the correspondence between these two variables. P values are expressed as follows: *P < 0.05; **P < 0.01; ***P < 0.001. R values are: SI, r = -0.46***; TF saturation, r = -0.48***; sTfR, r = 0.60***; ferritin, r = -0.28*; CRP, r = 0.29*; EPO, r = 0.38**. Kidney International 1999 56, 1113-1119DOI: (10.1046/j.1523-1755.1999.00627.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 Relationship between measured %HYPO and predicted %HYPO obtained from the regression equation logit %HYPO = -11.76 + 4.87 log sTfR + 0.40 log (EPO + 1) + 0.75 log (CRP + 1), (r = 0.69). Kidney International 1999 56, 1113-1119DOI: (10.1046/j.1523-1755.1999.00627.x) Copyright © 1999 International Society of Nephrology Terms and Conditions