Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma Milena Sokolowska, MD, PhD, Li-Yuan.

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Presentation transcript:

Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma Milena Sokolowska, MD, PhD, Li-Yuan Chen, PhD, Yueqin Liu, PhD, Asuncion Martinez-Anton, PhD, Carolea Logun, MSc, Sara Alsaaty, MSc, Rosemarie A. Cuento, MSc, Rongman Cai, PhD, Junfeng Sun, PhD, Oswald Quehenberger, PhD, Aaron M. Armando, MS, Edward A. Dennis, PhD, Stewart J. Levine, MD, James H. Shelhamer, MD Journal of Allergy and Clinical Immunology Volume 139, Issue 4, Pages 1379-1383 (April 2017) DOI: 10.1016/j.jaci.2016.09.031 Copyright © 2016 Terms and Conditions

Fig 1 LMW HA causes cPLA2α-dependent changes in the specific lipidomic profile of patients with severe asthma. A, Percentage of all cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (CYP 450), and nonenzymatic metabolites before and after LMW HA treatment. Each vertical line represents data from a single subject. B, LMW HA–induced lipid mediators significantly upregulated in patients with severe asthma. C, LMW HA lipidomic profile is cPLA2α dependent. *P < .05, as indicated. cPLA2i, cPLA2 inhibitor. Journal of Allergy and Clinical Immunology 2017 139, 1379-1383DOI: (10.1016/j.jaci.2016.09.031) Copyright © 2016 Terms and Conditions

Fig 2 LMW HA–dependent antimicrobial and antiviral signaling impairment in patients with severe asthma. A and B, Significantly enriched canonical pathways after LMW HA treatment in patients with severe asthma in comparison with nonasthmatic subjects. −log(B-H P-value), Benjamini-Hochberg false discovery rate. B, Percentage of genes in the data set creating enrichment, with the number at right stating the entire number of genes assigned to this pathway. C, Prediction model of the influence of changes in the experimental data set on the downstream antiviral and antimicrobial immunity. D, LMW HA–induced chemokines and cytokines following the trend of the prediction model. E, LMW HA–induced protein expression profile is partially dependent on cPLA2α. *P < .05, as indicated. Journal of Allergy and Clinical Immunology 2017 139, 1379-1383DOI: (10.1016/j.jaci.2016.09.031) Copyright © 2016 Terms and Conditions