Case study in pharmacognosy: Capsicum (chili pepper)
Ancient Mesoamerican people used chili peppers as a spice and medicinal
Later pepper rubs and plasters become a folk then patent medicine treatment for pain.
Sensory nerve terminal UCSF Study Suggests Capsaicin Significantly Reduces Debilitating Nerve Pain. Mice without capsaicin receptor don’t experience pain from heat (Science,2000). capsaicin receptor capsaicin activated channel Sensory nerve terminal neurogenic inflammation Substance P Ca++ Time capsaicin
The next step??