Tuberculosis Terpene Targets

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Presentation transcript:

Tuberculosis Terpene Targets Eric Oldfield Chemistry & Biology Volume 22, Issue 4, Pages 437-438 (April 2015) DOI: 10.1016/j.chembiol.2015.04.004 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Biosynthetic Route to 1-TbAd and N6-TbAd Rv3377c and Rv3378c are potential anti-virulence drug targets; 1-TbAd (6) and N6-TbAd (7) are produced in vivo in large amounts in Mtb-infected mice and are new targets for diagnosing tuberculosis that are likely be more specific than, e.g., tuberculin skin tests or interferon gamma release assays. Chemistry & Biology 2015 22, 437-438DOI: (10.1016/j.chembiol.2015.04.004) Copyright © 2015 Elsevier Ltd Terms and Conditions