The Wind God Promotes Lung Cancer

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The Wind God Promotes Lung Cancer Steven M. Frisch, Michael D. Schaller Cancer Cell Volume 25, Issue 5, Pages 551-552 (May 2014) DOI: 10.1016/j.ccr.2014.04.022 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Proposed Mechanism for Anoikis Resistance in Lung Cancer Cells via the Overexpression of Aiolos In normal epithelial cells, detachment engages a p66Shc-mediated response to the loss of cell tension that triggers anoikis (upper panel). With Aiolos expression in lung cancer cells, this pathway is obviated due to the repression of p66Shc as well as other cell adhesion related genes. Cancer Cell 2014 25, 551-552DOI: (10.1016/j.ccr.2014.04.022) Copyright © 2014 Elsevier Inc. Terms and Conditions