Therapeutic Translation of iPSCs for Treating Neurological Disease

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Presentation transcript:

Therapeutic Translation of iPSCs for Treating Neurological Disease Diana X. Yu, Maria C. Marchetto, Fred H. Gage Cell Stem Cell Volume 12, Issue 6, Pages 678-688 (June 2013) DOI: 10.1016/j.stem.2013.05.018 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Proposed Use of Microfluidic Chambers for Proper Reproduction of Hippocampal Circuitry Mircropatterning using biomaterials combined with of bioengineered cell chambers allow for isolation of dendrite and axons as well as compartmentalization of cellular subtypes to create highly organized structures that can mimic the organization of the endogenous tissue. Cell Stem Cell 2013 12, 678-688DOI: (10.1016/j.stem.2013.05.018) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Potential Applications of Reprogramming Technology in the Clinical Setting for Neurological Diseases Promising approaches include better understanding of disease biology, development of new diagnostic tools, formulation of new therapies, and personalized clinical interventions. Cell Stem Cell 2013 12, 678-688DOI: (10.1016/j.stem.2013.05.018) Copyright © 2013 Elsevier Inc. Terms and Conditions