Regression slopes between percentage changes in Bmax′/Kd′ (dependent variable) in VS and absolute regional brain metabolic activity in OFC (BA 11), anterior.

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Regression slopes between percentage changes in Bmax′/Kd′ (dependent variable) in VS and absolute regional brain metabolic activity in OFC (BA 11), anterior CG (BA 32), and DLPFC (BA 9) in controls (filled circles) and in alcoholics (open circles). Regression slopes between percentage changes in Bmax′/Kd′ (dependent variable) in VS and absolute regional brain metabolic activity in OFC (BA 11), anterior CG (BA 32), and DLPFC (BA 9) in controls (filled circles) and in alcoholics (open circles). Note that percentage decreases in the specific binding of [11C]raclopride (Bmax′/Kd′) reflect relative DA increases, and thus the regression conveys a negative correlation: the lower the metabolism, the greater the DA increases. Nora D. Volkow et al. J. Neurosci. 2007;27:12700-12706 ©2007 by Society for Neuroscience