Long-term effect of sodium hyaluronate (Hyalgan®) on osteoarthritis progression in a rabbit model D Amiel, Ph.D., T Toyoguchi, M.D., Ph.D., K Kobayashi,

Slides:

Advertisements

Similar presentations

Angiogenic activity of subchondral bone during the progression of osteoarthritis in a rabbit anterior cruciate ligament transection model M. Saito, T.

Advertisements

Intra-articular injection of the cyclooxygenase-2 inhibitor parecoxib attenuates osteoarthritis progression in anterior cruciate ligament-transected knee.

The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior.

Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury C.M. Haslauer,

D. N. Clements, B. Sc. , B. V. Sc. , S. D. Carter, Ph. D. , J. F

Adiabatic rotating frame relaxation of MRI reveals early cartilage degeneration in a rabbit model of anterior cruciate ligament transection J. Rautiainen,

Alleviation of osteoarthritis by calycosin-7-O-β-d-glucopyranoside (CG) isolated from Astragali radix (AR) in rabbit osteoarthritis (OA) model S.I. Choi,

Non-destructive evaluation of articular cartilage defects using near-infrared (NIR) spectroscopy in osteoarthritic rat models and its direct relation.

Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat.

Maturation-dependent change and regional variations in acoustic stiffness of rabbit articular cartilage: an examination of the superficial collagen-rich.

An Investigation of High Density Mineralised Protrusions in Human Cadaveric Knees by MRI and Microtomography N.P. Thomas, N. Jeffery, R. van 't Hof,

High-resolution MRI and micro-CT in an ex vivo rabbit anterior cruciate ligament transection model of osteoarthritis Danika L. Batiste, B.Sc, Alexandra.

Osteoarthritis and Cartilage

Cell deformation behavior in mechanically loaded rabbit articular cartilage 4 weeks after anterior cruciate ligament transection S.M. Turunen, S.-K.

An in vivo cross-linkable hyaluronan gel with inherent anti-inflammatory properties reduces OA cartilage destruction in female mice subjected to cruciate.

Protective effect of a new biomaterial against the development of experimental osteoarthritis lesions in rabbit: a pilot study evaluating the intra-articular.

Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis H. Mitsuyama, M.D., Ph.D., R.M. Healey, B.S.,

Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis 16 years after anterior cruciate ligament injury P. Neuman, L.E.

Increase in excitatory amino acid concentration and transporters expression in osteoarthritic knees of anterior cruciate ligament transected rabbits

Knee joint ultrasonography of the ACLT rabbit experimental model of osteoarthritis: relevance and effectiveness in detecting meniscal lesions C. Boulocher,

18F-FDG PET-CT and MRI co-registered knee assessment after ACL transection in an in vivo canine model M. Menendez, D. Clark, K. Binzel, B. Hettlich,

The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse S.S. Glasson, B.V.Sc., T.J. Blanchet, B.S., E.A.

Angiogenic activity of subchondral bone during the progression of osteoarthritis in a rabbit anterior cruciate ligament transection model M. Saito, T.

Biochemical effects of two different hyaluronic acid products in a co-culture model of osteoarthritis D.D. Greenberg, M.D., A. Stoker, Ph.D., S. Kane,

A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI J.-P.

Successful nonoperative management of chronic osteoarthritis pain of the knee: safety and efficacy of retreatment with intra-articular hyaluronans Mark.

Changes in biochemical markers and prediction of effectiveness of intra-articular hyaluronan in patients with knee osteoarthritis M. Hasegawa, M.D.,

Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model S. Elmorsy, T. Funakoshi, F. Sasazawa,

Effects of ACL interference screws on articular cartilage volume and thickness measurements with 1.5 T and 3 T MRI M.E. Bowers, B.S., G.A. Tung, M.D.,

Pharmacological effects of novel cross-linked hyaluronate, Gel-200, in experimental animal models of osteoarthritis and human cell lines K. Yoshioka,

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κBp65-specific siRNA L.X. Chen, Ph.D., L. Lin,

Basic Knee Arthroscopy Part 3: Diagnostic Arthroscopy

The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone K. Takebe, M.F. Rai, E.J. Schmidt,

Tenascin-C levels in synovial fluid are elevated after injury to the human and canine joint and correlate with markers of inflammation and matrix degradation

Articular cartilage degeneration following anterior cruciate ligament injury: a comparison of surgical transection and noninvasive rupture as preclinical.

The course of ultrasonographic abnormalities in knee osteoarthritis: 1 year follow up K. Bevers, J.W.J. Bijlsma, J.E. Vriezekolk, C.H.M. van den Ende,

Usefulness of specific OA biomarkers, Coll2-1 and Coll2-1NO2, in the anterior cruciate ligament OA canine model Y. Henrotin, J. Martel-Pelletier, P.

Efficacy and safety of intraarticular hyaluronic acid in the treatment of hip osteoarthritis: a systematic review J.C. Fernández López, M.D., Ph.D.,

Osteoarthritis and Cartilage

Cyclodextrin polysulphate protects articular cartilage in experimental lapine knee osteoarthritis S. Groeneboer, M.Sc., P. Pastoureau, M.D., Ph.D., E.

Characterization of pro-apoptotic and matrix-degradative gene expression following induction of osteoarthritis in mature and aged rabbits Dr. C.M. Robertson,

Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection J.T.A. Mäkelä, Z.S.

Articular cartilage MR imaging and thickness mapping of a loaded knee joint before and after meniscectomy Y. Song, M.S., J.M. Greve, M.S., D.R. Carter,

Observations of subchondral plate advancement during osteochondral repair: a histomorphometric and mechanical study in the rabbit femoral condyle Y.-S.

Chondroprotective activity of N-acetyl phenylalanine glucosamine derivative on knee joint structure and inflammation in a murine model of osteoarthritis

M. R. Doschak, Ph. D. , J. M. LaMothe, Ph. D. , D. M. L. Cooper, B. Sc

K.H. Collins, R.A. Reimer, R.A. Seerattan, T.R. Leonard, W. Herzog

Evaluations of radiographic joint space – do they adequately predict cartilage conditions in the patellofemoral joint of the patients undergoing total.

Quantitative MR T2 measurement of articular cartilage to assess the treatment effect of intra-articular hyaluronic acid injection on experimental osteoarthritis.

Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee C. Egloff, A. Sawatsky, T. Leonard,

Osteoarthritis development in novel experimental mouse models induced by knee joint instability S. Kamekura, M.D., K. Hoshi, M.D., Ph.D., T. Shimoaka,

Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis B. Doyran, W. Tong,

Intra-articular injection of interleukin-4 decreases nitric oxide production by chondrocytes and ameliorates subsequent destruction of cartilage in instability-induced.

Significance of the serum CTX-II level in an osteoarthritis animal model: a 5-month longitudinal study M.E. Duclos, O. Roualdes, R. Cararo, J.C. Rousseau,

K. Kuroki, C.R. Cook, J.L. Cook Osteoarthritis and Cartilage

Cartilage boundary lubrication of ovine synovial fluid following anterior cruciate ligament transection: a longitudinal study M. Atarod, T.E. Ludwig,

Intra-articular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content1 1 Supported by the Department.

Patellofemoral osteoarthritis 15 years after anterior cruciate ligament injury – a prospective cohort study P. Neuman, M.D., I. Kostogiannis, M.D., T.

Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis E. Calvo, M.D., I. Palacios,

Correlation between 18F-FDG and F-18 sodium fluoride (NaF) PET/MRI and gross morphology of the knee in a canine model of osteoarthritis. M.I. Menendez,

Weight-bearing asymmetry and vertical activity differences in a rat model of post- traumatic knee osteoarthritis C.B. Hamilton, M.A. Pest, V. Pitelka,

A comparison of intra-articular hyaluronan injection accuracy rates between three approaches based on radiographic severity of knee osteoarthritis Y.

Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate.

M. Nagao, C.W. Cheong, B.R. Olsen Osteoarthritis and Cartilage

Correlation between the MR T2 value at 4

Longitudinal assessment of femoral knee cartilage quality using contrast enhanced MRI (dGEMRIC) in patients with anterior cruciate ligament injury – comparison.

Preliminary study on diffraction enhanced radiographic imaging for a canine model of cartilage damage C. Muehleman, Ph.D., J. Li, M.D., Z. Zhong, Ph.D.

Knee kinematic differences in anterior cruciate ligament deficient subjects prior to reconstruction is associated with knee T1ρ cartilage relaxation time.

M. E. Bowers, B. S. , N. Trinh, M. S. , G. A. Tung, M. D. , F. A. C. R

The effects of intraarticularly injected sodium hyaluronate on levels of intact aggrecan and nitric oxide in the joint fluid of patients with knee osteoarthritis

Presentation transcript:

Long-term effect of sodium hyaluronate (Hyalgan®) on osteoarthritis progression in a rabbit model D Amiel, Ph.D., T Toyoguchi, M.D., Ph.D., K Kobayashi, M.D., Ph.D., K Bowden, A.A., M.E Amiel, M.A., R.M Healey, B.S., M.B.A. Osteoarthritis and Cartilage Volume 11, Issue 9, Pages 636-643 (September 2003) DOI: 10.1016/S1063-4584(03)00119-5

Fig. 1 Experimental design. ACLT=no injections following anterior cruciate ligament transection (ACLT); 5 HA=five weekly injections of hyaluronan (HA) beginning on the 4th week after surgery; 5 PBS=five weekly PBS injections beginning on the 4th week after surgery; 10 HA=10 weekly HA injections, one course of five injections beginning on the 4th week after surgery and one course of five injections beginning on the 13th week after surgery; 10 PBS=10 weekly PBS injections, one course of five injections beginning on the 4th week after surgery and one course of five injections beginning on the 13th week after surgery. Osteoarthritis and Cartilage 2003 11, 636-643DOI: (10.1016/S1063-4584(03)00119-5)

Fig. 2 Gross morphology of the meniscus in representative samples taken at 26 weeks after surgery from (a) Group 4 (10 HA+ACLT) and (b) Group 1 (ACLT only). Osteoarthritis and Cartilage 2003 11, 636-643DOI: (10.1016/S1063-4584(03)00119-5)

Fig. 3 DNA concentration in synovium from medial femoral condyles (mean±SD). Results are shown for ACLT and non-ACLT (untreated) control knees for each study group. N=10 for each group. Osteoarthritis and Cartilage 2003 11, 636-643DOI: (10.1016/S1063-4584(03)00119-5)

Fig. 4 Histomorphometric assessment of samples from the five treatment groups. (a) Cartilage height of the femoral condyles (mm) (mean±SD), (b) cartilage area of the femoral cartilage (mm2) (mean±SD), and (c) normalized cartilage roughness (RMS roughness/cartilage thickness) of the femoral cartilage (mm) (mean±SD). N=10 for each treatment group. Osteoarthritis and Cartilage 2003 11, 636-643DOI: (10.1016/S1063-4584(03)00119-5)