European Urology Oncology

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European Urology Oncology Genome-wide Association Study for Tumour Stage, Grade, Size, and Age at Diagnosis of Non–muscle-invasive Bladder Cancer Nadezda Lipunova, Anke Wesselius, Kar K. Cheng, Frederik-Jan van Schooten, Richard T. Bryan, Jean-Baptiste Cazier, Tessel E. Galesloot, Lambertus A.L.M. Kiemeney, Maurice P. Zeegers European Urology Oncology DOI: 10.1016/j.euo.2018.08.020 Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 1 A flowchart of main steps in the GWAS analysis. BCPP=Bladder Cancer Prognosis Programme; HWE=Hardy-Weinberg equilibrium; MAF=minor allele frequency; MIBC=muscle-invasive bladder cancer; NBCS=Nijmegen Bladder Cancer Study; NMIBC=non–muscle-invasive bladder cancer; PCA=principal component analysis; QC=quality control; SD=standard deviation; SNP=single nucleotide polymorphism; UBC=urinary bladder cancer. European Urology Oncology DOI: (10.1016/j.euo.2018.08.020) Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 2 Manhattan and quantile-quantile plots for tumour size (cm) in the BCPP cohort. Blue and red horizontal lines indicate p values of <5E–06 and <5E–08, respectively. Highlighted variant shows the SNP reaching statistical significance in the meta-analysis of BCPP and NBCS (independent association was observed in the BCPP, and no significant effect was detected among NBCS participants only). BCPP=Bladder Cancer Prognosis Programme; NBCS=Nijmegen Bladder Cancer Study; Q-Q=quantile-quantile; SNP=single nucleotide polymorphism. European Urology Oncology DOI: (10.1016/j.euo.2018.08.020) Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 3 Regional association plot for 13q13.3 locus with tumour size (cm) in NMIBC patients of the BCPP cohort (annotated SNP has reached statistical significance in the meta-analysis of BCPP and NBCS cohorts). BCPP=Bladder Cancer Prognosis Programme; NBCS=Nijmegen Bladder Cancer Study; SNP=single nucleotide polymorphism. European Urology Oncology DOI: (10.1016/j.euo.2018.08.020) Copyright © 2018 European Association of Urology Terms and Conditions