High Prevalence of Pathogenic Mutations in Patients with Early-Onset Dementia Detected by Sequence Analyses of Four Different Genes Ulrich Finckh, Tomas.

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High Prevalence of Pathogenic Mutations in Patients with Early-Onset Dementia Detected by Sequence Analyses of Four Different Genes Ulrich Finckh, Tomas Müller-Thomsen, Ulrike Mann, Christian Eggers, Josef Marksteiner, Wolfgang Meins, Giuliano Binetti, Antonella Alberici, Christoph Hock, Roger M. Nitsch, Andreas Gal The American Journal of Human Genetics Volume 66, Issue 1, Pages 110-117 (January 2000) DOI: 10.1086/302702 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigrees of the families with history of EOD and most likely pathogenic mutations described in this study. Numbers above the pedigree symbols indicate actual age or age at death. Numbers below the filled symbols indicate the probable age at onset in index patients (arrow) or their affected relatives. Results of mutation screening on the samples available for molecular analyses are indicated as + (mutation found) and − (mutation excluded) below the pedigree symbols. Available histopathological autopsy results of index patients are indicated by an asterisk (*). Reports about previous histopathological analyses in affected relatives are indicated by a pilcrow (¶). The American Journal of Human Genetics 2000 66, 110-117DOI: (10.1086/302702) Copyright © 2000 The American Society of Human Genetics Terms and Conditions