Volume 55, Issue 4, Pages 920-932 (October 2011) Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target  Paola Dongiovanni, Anna Ludovica Fracanzani, Silvia Fargion, Luca Valenti  Journal of Hepatology  Volume 55, Issue 4, Pages 920-932 (October 2011) DOI: 10.1016/j.jhep.2011.05.008 Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Proposed mechanisms explaining iron induced insulin resistance and metabolic alterations. FFAs, free fatty acids; ER, endoplasmic reticulum. Journal of Hepatology 2011 55, 920-932DOI: (10.1016/j.jhep.2011.05.008) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Proposed mechanisms explaining iron induced liver damage associated with steatosis and DIOS in hepatocytes (brown), macrophages (gray), and hepatic stellate cells (yellow). Cp, ceruloplasmin; Cu, copper; Fe-Tf, ferric-transferrin; Fp-1, ferroportin-1; HCC, hepatocellular carcinoma; HFE, hemochromatosis gene; HSCs, hepatic stellate cells; MDA, malonyl-dialdehyde; ROS, reactive oxygen species; SOD2, Mn superoxide dismutase; Tf-R, transferrin receptor. Journal of Hepatology 2011 55, 920-932DOI: (10.1016/j.jhep.2011.05.008) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

Fig. 3 Proposed additional mechanisms by which iron depletion improves glucose disposal and insulin sensitivity. InsR, insulin receptor; HIF-1α, hypoxia inducible factor-1α; Glut1, glucose transporter 1. Journal of Hepatology 2011 55, 920-932DOI: (10.1016/j.jhep.2011.05.008) Copyright © 2011 European Association for the Study of the Liver Terms and Conditions

Journal of Hepatology 2011 55, 920-932DOI: (10. 1016/j. jhep. 2011. 05 Copyright © 2011 European Association for the Study of the Liver Terms and Conditions