Preventive effect of nasal filters on allergic rhinitis: A randomized, double-blind, placebo- controlled crossover park study Peter Kenney, BSc, Ole Hilberg,

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Preventive effect of nasal filters on allergic rhinitis: A randomized, double-blind, placebo- controlled crossover park study Peter Kenney, BSc, Ole Hilberg, MD, DMSci, Anne Cathrine Laursen, BSc, Robert George Peel, PhD, Torben Sigsgaard, MD, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 6, Pages 1566-1572.e5 (December 2015) DOI: 10.1016/j.jaci.2015.05.015 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Trial protocol. Baseline scoring, FEV1 measurement, and safety checks were performed before blind device insertion. TNSSs and TOSSs were evaluated every 30 minutes. Visual analog scale (VAS) ratings were evaluated at hourly intervals from minute 60. The devices were removed after the final ratings at minute 450. FEV1 was recorded immediately thereafter, and adverse events were noted. Journal of Allergy and Clinical Immunology 2015 136, 1566-1572.e5DOI: (10.1016/j.jaci.2015.05.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Study flow diagram. Journal of Allergy and Clinical Immunology 2015 136, 1566-1572.e5DOI: (10.1016/j.jaci.2015.05.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Diurnal changes in grass pollen concentration for the 2 study days. Journal of Allergy and Clinical Immunology 2015 136, 1566-1572.e5DOI: (10.1016/j.jaci.2015.05.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Device evaluation. A, Time points for awareness of wearing a device. B, Time points for noticing breathing resistance in the 10 subjects who felt increased resistance. C, Intended period of use for the subjects who wanted to use the device. D, Proportion of subjects who felt completely confident in using the device. Journal of Allergy and Clinical Immunology 2015 136, 1566-1572.e5DOI: (10.1016/j.jaci.2015.05.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Mean TNSSs with SEMs as error bars. Devices were inserted after baseline scores (before 0 minutes). A, Day 1 for all 65 subjects. B, Day 2 for all 65 subjects. C, Day 1 for the 33 subjects with baseline TNSSs of 0 or 1. D, Day 2 for the 22 subjects with baseline TNSSs of 0 or 1. Journal of Allergy and Clinical Immunology 2015 136, 1566-1572.e5DOI: (10.1016/j.jaci.2015.05.015) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions