Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study Anna.

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Presentation transcript:

Sensitization to cat and dog allergen molecules in childhood and prediction of symptoms of cat and dog allergy in adolescence: A BAMSE/MeDALL study Anna Asarnoj, MD, PhD, Carl Hamsten, MSc, PhD, Konrad Wadén, MSc, Christian Lupinek, MD, PhD, Niklas Andersson, MSc, Inger Kull, RN, PhD, Mirela Curin, PhD, Josep Anto, MD, PhD, Jean Bousquet, MD, PhD, Rudolf Valenta, MD, Magnus Wickman, MD, PhD, Marianne van Hage, MD, PhD Journal of Allergy and Clinical Immunology Volume 137, Issue 3, Pages 813-821.e7 (March 2016) DOI: 10.1016/j.jaci.2015.09.052 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Prevalence (percentage) of IgE reactivity (≥0.3 ISU-E) to cat (A) and dog (B) allergen components at 4, 8, and 16 years of age (n = 779). Journal of Allergy and Clinical Immunology 2016 137, 813-821.e7DOI: (10.1016/j.jaci.2015.09.052) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Allergen-specific IgE levels (≥0.3 ISU-E) to cat (A) and dog (B) allergens in children with (white box plots) or without (gray box plots) symptoms to cat, dog, or both at 4, 8, and 16 years of age. Median IgE levels per age group (connected dotted lines) and P values are indicated. n, Number of children with positive results (N = 779); NA, not applicable (subgroup number <5 observations). Journal of Allergy and Clinical Immunology 2016 137, 813-821.e7DOI: (10.1016/j.jaci.2015.09.052) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Allergen-specific IgE levels (≥0.3 ISU-E) to cat (A) and dog (B) allergens in children with (white box plots) or without (gray box plots) symptoms to cat, dog, or both at 4, 8, and 16 years of age. Median IgE levels per age group (connected dotted lines) and P values are indicated. n, Number of children with positive results (N = 779); NA, not applicable (subgroup number <5 observations). Journal of Allergy and Clinical Immunology 2016 137, 813-821.e7DOI: (10.1016/j.jaci.2015.09.052) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Overlapping IgE reactivity (≥0.3 ISU-E) to cat and dog allergen components and median IgE levels to Fel d 1 (cat), Can f 1 (dog), and Can f 5 (dog) at 4, 8, and 16 years of age. Cat/dog symptom prevalence in the subgroups is shown (n = 779). Blue circles, IgE reactivity (≥0.3 ISU-E) to any cat allergen component: Fel d 1, Fel d 2, or Fel d 4. Green circles, IgE reactivity (≥0.3 ISU-E) to any dog allergen component: Can f 1, Can f 2, Can f 3, Can f 5, or Can f 6. Journal of Allergy and Clinical Immunology 2016 137, 813-821.e7DOI: (10.1016/j.jaci.2015.09.052) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Longitudinal logistic regression. Crude and adjusted ORs for IgE sensitizations to cat and dog allergen (ISU-E ≥0.3) at 4 and 8 years of age in relation to reported cat/dog allergy at 16 years of age (n = 779). *Adjusted for concomitant sensitization to the other cat or dog components, respectively. For sensitization matrix, see Table E5. Journal of Allergy and Clinical Immunology 2016 137, 813-821.e7DOI: (10.1016/j.jaci.2015.09.052) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 A and B, Likelihood (y-axis, percentage) of reporting symptoms to cat at 16 years of age depending of the number of IgE-reactive cat allergens (Fel d 1, Fel d 2, and Fel d 4) and ImmunoCAP cat extract sensitization (x-axes) at 4 (Fig 5, A) and 8 (Fig 5, B) years of age. C and D, Likelihood (y-axis, percentage) of reporting symptoms to dog at 16 years of age depending of the number of IgE-reactive dog allergens (Can f 1, Can f 2, Can f 3, Can f 5, and Can f 6) and ImmunoCAP dog extract sensitization (x-axes) at 4 (Fig 5, C) and 8 (Fig 5, D) years of age. Numbers, ORs, and 95% CIs are shown (n = 779). Journal of Allergy and Clinical Immunology 2016 137, 813-821.e7DOI: (10.1016/j.jaci.2015.09.052) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Flow chart of children in the BAMSE cohort study base (n = 4089) and study population (n = 779). Journal of Allergy and Clinical Immunology 2016 137, 813-821.e7DOI: (10.1016/j.jaci.2015.09.052) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions