Volume 73, Pages S131-S136 (April 2008)

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Presentation transcript:

Volume 73, Pages S131-S136 (April 2008) Amino-acid-based peritoneal dialysis solution improves amino-acid transport into skeletal muscle M. Asola, K. Virtanen, K. Någren, S. Helin, M. Taittonen, H. Kastarinen, B. Anderstam, J. Knuuti, K. Metsärinne, P. Nuutila Kidney International Volume 73, Pages S131-S136 (April 2008) DOI: 10.1038/sj.ki.5002614 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 A transverse section of the femoral region. Black ovals denote the regions of interest. Kidney International 2008 73, S131-S136DOI: (10.1038/sj.ki.5002614) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 The AA uptake into skeletal muscle with both dialysis solutions in the fasting state and during insulin stimulation (clamp). The uptake of all AAs was significantly higher during AA dialysis solution than glucose-based solution, during both fasting and insulin stimulation. In system A AAs, the uptake in the fasting condition was significantly higher when AA solution was used than during glucose-based solution, and there was a trend toward a higher uptake during insulin stimulation when AA solution was used. All AAs, sum of concentrations of all AAs; sysA, sum of concentrations of six AAs that typically use system A for their transport; G, treatment with glucose-based solution; AA, treatment with AA-based solution. Kidney International 2008 73, S131-S136DOI: (10.1038/sj.ki.5002614) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 3 Plasma AA concentrations with both dialysis solutions in the fasting state and during insulin stimulation (clamp). The concentrations of both AA groups were significantly higher during AA dialysis solution than glucose-based solution, during both fasting and insulin stimulation. All AAs, sum of concentrations of all AAs; sysA, sum of concentrations of six AAs that typically use system A for their transport; G, treatment with glucose-based solution; AA, treatment with AA-based solution. Kidney International 2008 73, S131-S136DOI: (10.1038/sj.ki.5002614) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 4 Study design. G, glucose-based dialysis fluid; N, 1.1% AA dialysis fluid. Kidney International 2008 73, S131-S136DOI: (10.1038/sj.ki.5002614) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 5 PET scans. The arrows denote the time of intravenous injections of positron-emitting tracer [11C]MeAIB. The hatched rectangles denote the time period of dynamic scanning. Kidney International 2008 73, S131-S136DOI: (10.1038/sj.ki.5002614) Copyright © 2008 International Society of Nephrology Terms and Conditions