This Month in Gastroenterology Jan Tack, John M. Carethers  Gastroenterology  Volume 134, Issue 4, Pages 901-904 (April 2008) DOI: 10.1053/j.gastro.2008.02.042 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Progression rate of premalignant gastric lesions to gastric cancer in 92,250 patients with premalignant gastric lesions. Gastroenterology 2008 134, 901-904DOI: (10.1053/j.gastro.2008.02.042) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Receiver operating characteristic curves for the use of transient elastography in the diagnosis of cirrhosis, severe fibrosis, and significant fibrosis. Dots indicate 1-specificity and sensitivity of the single studies used in the meta-analysis. Gastroenterology 2008 134, 901-904DOI: (10.1053/j.gastro.2008.02.042) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Effects of hormonal substitution of hypophysectomized (Hx) rats on serum plant sterols. Hx-rats (n = 52) were substituted with growth hormone (GH, 1.5 mg/kg per day), l-thyroxine (T4, 42 μg/kg per day) and cortisone (C, 400 μg/kg per day) for 1 week. Intact rats (I; n = 5), and the Hx-control group received subcutaneous injections of NaCl. ¡P < .05 versus intact; *P < .01; **P < .001 versus Hx; ns, not significant. Gastroenterology 2008 134, 901-904DOI: (10.1053/j.gastro.2008.02.042) Copyright © 2008 AGA Institute Terms and Conditions

Figure 4 Schematic representation of the bile salt export pump (BSEP) with location of mutations identified in the study. Schematic generated using TOPO2 software. Protein topology predicted by comparison with multidrug resistant protein MDR1. Transmembrane spans predicted to fit the accepted topology using TopPred II. Singly mutated residues represented as colored residues; founder/recurrent mutations indicted by arrows. For insertions/deletions the affected residue is indicated, for splice sites the adjacent amino acid. Color key: Blue, missense; red, stop; green, insertion/deletion; orange, splice site; black, several different mutations at a site; purple, Walker A, B, and ABC motifs. Gastroenterology 2008 134, 901-904DOI: (10.1053/j.gastro.2008.02.042) Copyright © 2008 AGA Institute Terms and Conditions