“I want LONGER Telomeres” Oprah Winfrey -November 1st, 2007 Long Telomeres Get ready to show “bumper sticker” Short Telomeres

Telomere Biology: The Emerging Paradigm Shift Presentation by: Noel Thomas Patton Founder and Chairman Telomerase Activation Sciences, Inc. Jan. 26, 2010 in New York I am not a scientist or a doctor. I am a businessman. But some of the best scientists in the world such as Dr. Calvin Harley are advising us. I got interested in telomere biology when I turned 50 and started to notice the ugly ravages of age peeking around the corner. I wanted to do something to save my own ass. That was 14 years ago and since then I have personally worked with no salary and invested millions of dollars to bring our telomerase activating product,TA-65 to market. My personal goal is to play a significant role in the battle to “cure aging.”

What can be done to keep Telomeres long? Lead a healthy lifestyle Activate Telomerase Do what your doctor says: Eat well, exercise, avoid stress, don’t smoke, and so on. To activate telomerase it is possible to do gene therapy on cells in a lab, but that is not currently possible in live humans; for living people there is only one thing available, our product TA-65.

Telomerase can be turned on with a nutraceutical 2000: The Corporation discovered TA-65 a single molecule that turns on Telomerase 2002: T.A. Sciences exclusively licensed TA-65 from Geron 2007: TA-65 commercialized as a nutraceutical capsule through licensee doctors The TA-65 molecule comes from the Astragalus plant that has been in the food chain for over 1,000 years. Because TA-65 is a nutraceutical, it does not need to go through the FDA. We don’t have to wait another decade or more before people can do something about short telomeres. Aging and resulting frailty has been thrust on us by nature without our consent. The resulting decline of vitality and suffering is one of the more tragic aspects of the human condition. I am proud to have an opportunity to do something positive about it.

How does TA-65 Work? TA-65 activates Telomerase in certain cells and lengthens Telomeres and/or slows their rate of loss. This allows cells to live longer in a more “youthful” state.

Schematic of Cell Rejuvenation Gene Expression Comparison: 10,000 genes on a chip Gene therapy depicted Telomerized (rejuvenated to “Young”) Young Old (notice overall changes ) Actual data in: Funk et al, Exp Cell Res, 2000

Is TA-65 the “Fountain of Youth”? No, not in the case of a total human being: TA-65 activates Telomerase in selected biological systems, not in every cell of the entire organism But, TA-65 users have seen statistically significant improvements in their immune system, bone density, sexual performance, and several other key areas The data from current TA-65 users has been evaluated scientifically by Calvin Harley, PhD. and clinically by Joseph Raffaele, M.D.

Is it the “Holy Grail?” Maybe. For the first time in mankind’s age-old quest, something has the potential to extend maximum human lifespan When cells in a petri dish in the lab have a constant supply of TA-65, the Hayflick limit is extended and death from old age is delayed

Telomerase can do some pretty powerful things Short Telomeres Gray and Thinning Hair Weakened Immune System Intestinal Atrophy Reduced Spleen Size Decreased Wound Healing Decreased Lifespan! These Mice are the Same Age! The one on top has no Telomerase. Long Telomeres Rudolph, et al Cell 1999 Samper, et al EMBO rep 2001 Slide courtesy of Bill Andrews

Skin Reconstitution: Old Cells Become “Young” Telomerized Human skin on a mouse Young Slide courtesy of Bill Andrews Funk et al, Exp Cell Res, 2000

Who takes TA-65? Who should take TA-65? Knowledgeable professionals capable of determining risk/reward ratios About half of our clients are MD’s or PhD’s Several are well known Telomere Biologists Who should take TA-65? Anyone over 40 who wants to intervene in age related decline Particularly those who have measured their Telomeres and found them to be short Who takes: All our clients are informed about Telomere Biology. We do no advertising and make no unsubstantiated claims. Who should take: In general, the shorter one’s telomeres, the more they are likely to benefit from TA-65

These graphs show some of the results of a double blind, placebo controlled study we did in 2005. This pivotal study is what prompted us to settle on the specific TA-65 molecule. I should mention that our license from Geron gives us rights to ALL their Telomerase Activators and we could have chosen any other molecule they were working on. TA-65 is in no way a second rate activator. Now let’s move on to current data.

Safety 5 years of development and safety testing before introducing TA-65 Hundreds of clients taking TA-65 Some for as long as 3 years Not a single adverse reaction reported by our licensed physicians Not a single diagnosis of new cancer Not a single report of increased cancer load for clients who already had cancer Now I want to play a short clip from a presentation made by Dr. Bill Andrews, a noted Telomere Biologist who is the co-discoverer of the telomerase gene.

Verified by Independent research Thank you Bill. And by the way Bill deserves a special thanks. He was the first 3rd party scientist to recognize the importance of TA-65 and to independently verify that TA-65 actually works as a telomerase activator. And he was the first paying customer to go on TA-65. There is one thing he said that I want to comment on. Bill said that TA-65 doesn’t turn on telomerase “a lot.” This is exactly what we want to do. In cancer cells the telomerase gene is turned on full blast and turned on permanently. That makes the cell immortal. TA-65 turns it on transiently, when you stop taking it, the gene shuts off again. We do not immortalize cells and we don’t want to. So I have tried to show that TA-65 is a telomerase activator and it is safe. Now here are some of the results of taking TA-65.

People currently taking TA-65 have seen the following results* Lengthening of the Shortest Telomeres. (These are the ones that really matter; it only takes one short Telomere out of the 92 in every cell to send a cell into crisis) Improved Immune system: In particular the % and absolute number of senescent CD8+/28- cells has significantly decreased. This is a reversal of what normally happens with age Improved bone density  Improved cardiovascular and hormonal biomarkers that normally show decline with age There are also anecdotal results, such as improved energy and athletic performance, but these effects are not universal and vary among individuals *Human trial results substantiating these claims to be published in a peer reviewed scientific journal Notice that TA-65 has a number of significant effects that cross over between different organ systems. This is not surprising because the method of action is universal. In theory a telomerase activator should be beneficial to each and every cell it gets into.

TA-65 The Only Proven Telomerase Activating Product Available through licensed doctors Thanks to: Calvin Harley Bill Andrews Maria Blasco for their contributions to Telomere Biology and to this presentation So in closing: Telomerase activation has huge scientific and medical potential and TA-65 is at the forefront of this new paradigm. Thank you. Any Questions?