Improving outcomes of severe infections by multidrug-resistant pathogens with polyclonal IgM-enriched immunoglobulins E.J. Giamarellos-Bourboulis, N.

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Improving outcomes of severe infections by multidrug-resistant pathogens with polyclonal IgM-enriched immunoglobulins E.J. Giamarellos-Bourboulis, N. Tziolos, C. Routsi, C. Katsenos, I. Tsangaris, I. Pneumatikos, G. Vlachogiannis, V. Theodorou, A. Prekates, E. Antypa, V. Koulouras, N. Kapravelos, C. Gogos, E. Antoniadou, K. Mandragos, A. Armaganidis Clinical Microbiology and Infection Volume 22, Issue 6, Pages 499-506 (June 2016) DOI: 10.1016/j.cmi.2016.01.021 Copyright © 2016 The Authors Terms and Conditions

Fig. 1 Case–control matching process. Abbreviations: CCI, Charlson's Co-morbidity Index; IgGAM, IgM-enriched polyclonal immunoglobulin preparation; MDR, multidrug-resistant. Clinical Microbiology and Infection 2016 22, 499-506DOI: (10.1016/j.cmi.2016.01.021) Copyright © 2016 The Authors Terms and Conditions

Fig. 2 Survival plots for the patients treated with an IgM-enriched polyclonal immunoglobulin preparation (IgGAM) and the comparator group until day 28; statistical comparison between the two groups is shown. Clinical Microbiology and Infection 2016 22, 499-506DOI: (10.1016/j.cmi.2016.01.021) Copyright © 2016 The Authors Terms and Conditions

Fig. 3 Time to breakthrough bacteraemia for cases treated with an IgM-enriched polyclonal immunoglobulin preparation (IgGAM) and matched comparators; statistical comparison between the two groups is shown. Clinical Microbiology and Infection 2016 22, 499-506DOI: (10.1016/j.cmi.2016.01.021) Copyright © 2016 The Authors Terms and Conditions