Prediction of Prognosis and Surgical Indications for Pulmonary Metastasectomy From Colorectal Cancer Toshihiko Iizasa, MD, Makoto Suzuki, MD, Shigetoshi.

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Prediction of Prognosis and Surgical Indications for Pulmonary Metastasectomy From Colorectal Cancer Toshihiko Iizasa, MD, Makoto Suzuki, MD, Shigetoshi Yoshida, MD, Shinichiro Motohashi, MD, Kazuhiro Yasufuku, MD, Akira Iyoda, MD, Kiyoshi Shibuya, MD, Kenzo Hiroshima, MD, Yukio Nakatani, MD, Takehiko Fujisawa, MD The Annals of Thoracic Surgery Volume 82, Issue 1, Pages 254-260 (July 2006) DOI: 10.1016/j.athoracsur.2006.02.027 Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Overall survival curves for patients (n = 75) with pulmonary metastasis from colorectal cancer. (A) Overall 5- and 10-year survival rates were 41.3% and 35.2%, respectively, after resection of pulmonary metastases. (B) Overall 5- and 10-year survival rates were 73.1% and 40.3%, respectively, after initial colorectal resection. The Annals of Thoracic Surgery 2006 82, 254-260DOI: (10.1016/j.athoracsur.2006.02.027) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Survival curves according to serum carcinoembryonic antigen (CEA) concentration. (A) The 5- and 10-year survival rates after pulmonary resection were 11.2% and no survivors, respectively, for patients with elevated CEA (thin line); rates were 65.0% and 59.6%, respectively, for patients without elevation (thick line). (B) The 5- and 10-year survival rates after primary resection were 61.1% and 14.9%, respectively, for patients with elevated CEA (thin line); rates were 81.5% and 65.0%, respectively, for patients without elevation (thick line). The Annals of Thoracic Surgery 2006 82, 254-260DOI: (10.1016/j.athoracsur.2006.02.027) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Survival curves according to site of primary tumor. (A) The 5- and 10-year survival rates after pulmonary resection were 52.2% and 47.4%, respectively, for patients with primary tumor in the colon (thin line); rates were 29.5% and no survivors, respectively, for patients with primary tumor in the rectum (thick line). (B) The 5- and 10-year survival rates after primary resection were 84.4% and 54.5%, respectively, for patients with primary colon tumors (thin line); rates were 61.2% and 23.6%, respectively, for patients with primary tumors in the rectum (thick line). The Annals of Thoracic Surgery 2006 82, 254-260DOI: (10.1016/j.athoracsur.2006.02.027) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Survival curves according to prior hepatectomy for hepatic metastasis. (A) The 5- and 10-year survival rates after pulmonary resection were 31.6% and 31.6%, respectively, for patients who underwent resection of hepatic metastases (thick line); rates were 44.0% and 36.7%, respectively, for patients who did not undergo such surgery (thin line). (B) The 5- and 10-year survival rates after pulmonary resection were 66.6% and 31.7%, respectively, for patients who underwent resection of hepatic metastases (thick line); rates were 75.4% and 43.3%, respectively, for patients who did not undergo such surgery (thin line). The Annals of Thoracic Surgery 2006 82, 254-260DOI: (10.1016/j.athoracsur.2006.02.027) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions