Ramifications of adolescent menstrual cycles ≥42 days in young adults John A. Morrison, Ph.D., Charles J. Glueck, M.D., Stephen Daniels, M.D., Ph.D., Ping Wang, Ph.D., Davis Stroop, M.Sc.  Fertility and Sterility  Volume 96, Issue 1, Pages 236-240.e1 (July 2011) DOI: 10.1016/j.fertnstert.2011.04.005 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Free T and DHEAS at age 14, by categories of age 14–19 annual reports of menstrual cycles ≥42 days (0, 1, 2, or ≥3). Unadjusted mean ± SD values are displayed. P values (analysis of variance adjusting for race): free T: ≥3 reports .0017 vs. 0, .0069 vs. 1, .0083 vs. 2; DHEAS: ≥3 reports .0054 vs. 0, .050 vs. 1, .0007 vs. 2; 2 vs. 1.038. Fertility and Sterility 2011 96, 236-240.e1DOI: (10.1016/j.fertnstert.2011.04.005) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Body mass index (BMI) and waist circumference at ages 14, 19, and 25 years, by categories of age 14–19 annual reports of menstrual cycles ≥42 days (0, 1, 2, or ≥3). Unadjusted mean ± SD values are displayed. P values (analysis of variance adjusting for race): BMI at age 14: ≥3 reports .0003 vs. 0, .0015 vs. 1, .0006 vs. 2; BMI at age 19: ≥3 reports .003 vs. 0, .03 vs. 1; BMI at age 25: ≥3 reports .0004 vs. 0, .0042 vs. 1, .015 vs. 2; waist circumference at age 14: ≥3 reports .0002 vs. 0, .0008 vs. 1, .0008 vs. 2; waist circumference at age 19: ≥3 reports .0005 vs. 0, .007 vs. 1, .02 vs. 2; waist circumference at age 25: ≥3 reports .0002 vs. 0, .0018 vs. 1, .0079 vs. 2. Fertility and Sterility 2011 96, 236-240.e1DOI: (10.1016/j.fertnstert.2011.04.005) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Glucose (at ages 10, 19, and 24), insulin (at ages 10–16, 19, and 25), and homeostasis model assessment insulin resistance (HOMA-IR; at ages 10, 19, and 24) by categories of age 14–19 annual reports of menstrual cycles ≥42 days (0, 1, 2, or ≥3). Unadjusted mean ± SD values are displayed. P values (analysis of variance adjusting for race): glucose at age 24: ≥3 reports <.0001 vs. 0, <.0001 vs. 1, <.0001 vs. 2; insulin at ages 10–16: ≥3 reports .047 vs. 0, 1 vs. 0 .026; insulin at age 19: ≥3 reports .010 vs. 0, 1 vs. 0 .023; insulin at age 25: ≥3 reports <.0001 vs. 0, <.0001 vs. 1, <.0001 vs. 2; HOMA-IR at age 19: ≥3 reports .027 vs. 0, 1 vs. 0 .015; HOMA-IR at age 24: ≥3 reports <.0001 vs. 0, <.0001 vs. 1, <.0001 vs. 2. Fertility and Sterility 2011 96, 236-240.e1DOI: (10.1016/j.fertnstert.2011.04.005) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions