Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers Yung-Chie Lee, MD, PhD, Yih-Leong Chang, MD, Shi-Ping.

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Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers Yung-Chie Lee, MD, PhD, Yih-Leong Chang, MD, Shi-Ping Luh, MD, Jang-Ming Lee, MD, Jin-Shing Chen, MD The Annals of Thoracic Surgery Volume 68, Issue 2, Pages 343-347 (August 1999) DOI: 10.1016/S0003-4975(99)00618-9

Fig 1 Immunohistochemical study of a pulmonary adenocarcinoma in a 35-year-old female patient, who died 23 months postoperatively. (A) A moderately differentiated adenocarcinoma shows nuclear staining for P53 in the lung tumor (66×). (B) Negative staining for Rb in the lung tumor (66×). The Annals of Thoracic Surgery 1999 68, 343-347DOI: (10.1016/S0003-4975(99)00618-9)

Fig 2 Survival curves of P53-positive and P53-negative NSCLC patients after operation (p < 0.0001). The Annals of Thoracic Surgery 1999 68, 343-347DOI: (10.1016/S0003-4975(99)00618-9)

Fig 3 Survival curves of Rb-positive and Rb-negative NSCLC patients after operation (p < 0.05). The Annals of Thoracic Surgery 1999 68, 343-347DOI: (10.1016/S0003-4975(99)00618-9)

Fig 4 Survival curves of P53-positive and P53-negative stage 1 NSCLC patients after operation (p < 0.0001). The Annals of Thoracic Surgery 1999 68, 343-347DOI: (10.1016/S0003-4975(99)00618-9)

Fig 5 Survival curves of P53-positive and P53-negative stage 2 NSCLC patients after operation (p = 0.13). The Annals of Thoracic Surgery 1999 68, 343-347DOI: (10.1016/S0003-4975(99)00618-9)

Fig 6 Survival curves of P53-positive and P53-negative stage 3 NSCLC patients after operation (p = 0.44). The Annals of Thoracic Surgery 1999 68, 343-347DOI: (10.1016/S0003-4975(99)00618-9)