Large-scale testing of women in Copenhagen has not reduced the prevalence of Chlamydia trachomatis infections  H. Westh, H.J. Kolmos  Clinical Microbiology and Infection  Volume 9, Issue 7, Pages 619-624 (July 2003) DOI: 10.1046/j.1469-0691.2003.00554.x Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 The age-specific percentage of women in Copenhagen examined every year at least once for chlamydial infection (median and range for the years 1995–99). Clinical Microbiology and Infection 2003 9, 619-624DOI: (10.1046/j.1469-0691.2003.00554.x) Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 The positive sample rate for detection of Chlamydia trachomatis infections in women aged 15–49 years in Copenhagen (CPH), Denmark for the years 1995–99 (median and range). Also shown are the total number of women of each age (average of the 5-year period) living in Copenhagen and the percentage of Danish women of a given age living in Copenhagen. Clinical Microbiology and Infection 2003 9, 619-624DOI: (10.1046/j.1469-0691.2003.00554.x) Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 3 The performance of EIA with a sensitivity of 80% and a specificity of 99% compared with a genomic detection assay with a sensitivity of 95% and a specificity of 99.5%. The positive predictive value (PPV) and negative predictive value (NPV) of a test result were calculated using the sensitivities and specificities of the tests and the age-specific estimate of prevalence of chlamydial infection from Figure 2. Clinical Microbiology and Infection 2003 9, 619-624DOI: (10.1046/j.1469-0691.2003.00554.x) Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 4 The average number of Chlamydia trachomatis infections diagnosed per age and the estimated impact of change of detection method to genomic detection (data from 1995 to 1999 combined into one graph). For comparison, the calculated maximum number of women with C. trachomatis infection in Copenhagen is shown. The calculated maximum is based on the average of the years 1995–99 and the assumption that the prevalence of C. trachomatis infections in all women is the same as the positive rate found by large-scale opportunistic testing of 19.3% of the female population per year. Clinical Microbiology and Infection 2003 9, 619-624DOI: (10.1046/j.1469-0691.2003.00554.x) Copyright © 2003 European Society of Clinical Infectious Diseases Terms and Conditions