Hydrogen bonds break (DNA polymerase)

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Presentation transcript:

I. DNA Replication http://ncc.gmu.edu/dna/repanim.htm Hydrogen bonds break (DNA polymerase) Free nucleotides pair w/ complementary base pairs 2 strands of identical DNA http://ncc.gmu.edu/dna/repanim.htm 5.http://207.207.4.198/pub/flash/24/menu.swf

II. Mutations A change in the genetic code Mutagen: substance that causes a mutation 3 Types: DNA Chromosome Non-DisJunction

1. DNA Mutation A. Point Mutation: change in a single base pair THE DOG BIT THE CAT THE DOG BIT THE CAR

B. Frameshift Mutation: 1. Single base is added or deleted 2. All other bases shift one spot THE DOG BIT THE CAT THE DGB ITT HEC AT? or THE DOR GBI TTH ECA

2. Chromosome Mutations: a. Change in the chromosome b. Chromosome: 5 – 10 % DNA 90 – 95% protein

c. 3 types: 1. Deletion: portion missing 2. Inversion: portion inverted on chromosome 3. Translocation: portion moves to the other homologous chrom.

3. Non-Disjunction: a. Failure of chrom to separate properly during meiosis b. Incorrect number of chrom in egg/sperm c. Examples: Trisomy 21 (Down’s Syndrome)

http://images. google. com/images http://images.google.com/images?gbv=2&hl=en&q=non-disjunction+mutation