Skin erythrodiapedesis during chronic venous disorders

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Skin erythrodiapedesis during chronic venous disorders Alberto Caggiati, MD, Marco Franceschini, MD, Rosemarie Heyn, VMD, Caterina Rosi, BsC Journal of Vascular Surgery Volume 53, Issue 6, Pages 1649-1653 (June 2011) DOI: 10.1016/j.jvs.2011.01.045 Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 1 Erythrodiapedesis (ED) in the skin of chronic venous disorder (CVD) legs. A, ED grade 1: Erythrocytes crossing the venular wall (arrows). Hematoxylin and eosin (HE), original magnification: ×40. B, ED grade 2: Scattered erythrocytes in the interstitial tissue (arrows). HE, original magnification: ×40. C, ED grade 3: Cluster of erythrocytes in the interstitial tissue. Perl's, original magnification: ×20. D, ED grade 4: Microhemorrhage in the skin surrounding an active ulcer. HE, original magnification ×20. Journal of Vascular Surgery 2011 53, 1649-1653DOI: (10.1016/j.jvs.2011.01.045) Copyright © 2011 Society for Vascular Surgery Terms and Conditions

Fig 2 Erythrodiapedesis and iron deposition and in chronic venous disorder (CVD) legs. A, Hemosiderin granules are visible within macrophages. No extravasated erythrocytes are visible. Hematoxylin and eosin (HE), original magnification: ×40. B, The corresponding Perl's stained section ×40. C, Perl's diffusely stains interstitial spaces where clusters of extravasated erythrocytes are present (original magnification ×20). D, Skin biopsy from a C3 leg. Despite the severe dermal edema, no extravasated erythrocytes are visible. HE, original magnification: ×40. Journal of Vascular Surgery 2011 53, 1649-1653DOI: (10.1016/j.jvs.2011.01.045) Copyright © 2011 Society for Vascular Surgery Terms and Conditions