Volume 9, Issue 4, Pages (September 2003)

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Volume 9, Issue 4, Pages 221-227 (September 2003) Fermented grain products, production, properties and benefits to health  Yukiko Minamiyama, Shigekazu Takemura, Toshikazu Yoshikawa, Shigeru Okada  Pathophysiology  Volume 9, Issue 4, Pages 221-227 (September 2003) DOI: 10.1016/S0928-4680(03)00022-1

Fig. 1 O2− scavenging activity of plasma for animals fed on normal diet and AOB-containing diet. Superoxide was generated by 0.1 mM hypoxanthine and xanthine oxidase (0.1 U/ml). Data from [1]. Pathophysiology 2003 9, 221-227DOI: (10.1016/S0928-4680(03)00022-1)

Fig. 2 Comparison of raw materials of AOB and processed AOB on the inhibitory effect of lipid peroxidation. Raw materials (10 μg/ml) of AOB and the processed AOB were examined for their inhibitory effects of rat brain lipid peroxidation. Values are mean±S.E. of % inhibition of TBA-reactive substances with control level being 0%. Pathophysiology 2003 9, 221-227DOI: (10.1016/S0928-4680(03)00022-1)

Fig. 3 Effects of AOB on renal injury induced by ischemia/reperfusion. Rats given oral administration of AOB-mixed diet, 5 g of AOB in 15 g normal diet/rat per day, were used and we compared them with control animals. After 5 g of AOB was given for 7 days, renal injury was elicited in male Sprague–Dawley rats (200 g) by 1 h occlusion and 24 h reperfusion of the left renal artery and vein. (A) Histochemical determination of lipid peroxidation with cold Shiff's reagent in the kidney using image analyzer. (B) Changes in levels of BUN. Values are mean±S.E.M. *, P<0.05; **, P<0.01 vs. normal rats. Pathophysiology 2003 9, 221-227DOI: (10.1016/S0928-4680(03)00022-1)

Fig. 4 Effect of AOB on Fe-NTA induced renal injury. Many of the proximal tubules in rats obtained 24 h after Fe-NTA injection showed a classic picture of acute tubular necrosis. Many of the tubules were without their nuclei. Pathophysiology 2003 9, 221-227DOI: (10.1016/S0928-4680(03)00022-1)

Fig. 5 Effect of AOB on cisplatin-induced renal failures. Cisplatin (5 mg/kg) intravenously administered to Wistar rats with or without AOB. Figure shows plasma levels of creatinine and BUN. Oral administration of AOB (6.5% AOB containing diet) for 5 days markedly inhibited the renal dysfunction by cisplatin. Open circle, cisplatin; closed square, AOB+cisplatin. *, P<0.05. Pathophysiology 2003 9, 221-227DOI: (10.1016/S0928-4680(03)00022-1)

Fig. 6 Effect of AOB on cisplatin-induced small intestinal injury. Injection of cisplatin produced atrophic mucosa with fibrosis, inflammatory cell infiltration, lymph dilatation and regenerative epithelium 5 days after injection. This figure resembles the regenerative stage of inflammatory bowel disease. AOB (6.5% AOB containing diet) for 5 days markedly inhibited the injury by cisplatin. Pathophysiology 2003 9, 221-227DOI: (10.1016/S0928-4680(03)00022-1)

Fig. 7 Effect of AOB on LPS induced liver injury and survival. LPS (10 mg/kg) was intravenously administered into rats. Under light ether anesthesia, plasma samples were collected via the abdominal aorta at the indicated times. AOB was given orally for 3 days (1 g/day) with basal diet before the experiments. Values are means±S.E. (n=5–10). Open circle, LPS-treated; closed circle, AOB-treated. *, P<0.05; **, P<0.01 as compared with LPS-treated group. Pathophysiology 2003 9, 221-227DOI: (10.1016/S0928-4680(03)00022-1)