Volume 54, Issue 4, Pages (October 1998)

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Volume 54, Issue 4, Pages 1337-1343 (October 1998) Role of cytokines in the response to erythropoietin in hemodialysis patients Marian Goicoechea, Julio Martin, Patricia de Sequera, Juan A. Quiroga, Alberto Ortiz, Vicente Carreño, Carlos Caramelo Kidney International Volume 54, Issue 4, Pages 1337-1343 (October 1998) DOI: 10.1046/j.1523-1755.1998.00084.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 (A) Interleukin-12 (IL-12) production by peripheral blood mononuclear cells (PBMC) in groups A1, A2, B1and B2. The cutoff was 60 U/kg/week for groups A1 and B1, and the cutoff was 100 U/kg/week for groups A2 and B2. (B) Interferon gamma (IFN-γ) production by PBMC in groups A1, A2, B1 and B2. The cutoff was 60 U/kg/week for groups A1 and B1, and the cutoff was 100 U/kg/week for groups A2 and B2. (C) Tumor necrosis factor alpha (TNF-α) production by PBMC in groups A1, A2, B1 and B2. The cutoff was 60 U/kg/week for groups A1 and B1, and the cutoff was 100 U/kg/week for groups A2 and B2. Symbols are: () group A; (▪) group B. Kidney International 1998 54, 1337-1343DOI: (10.1046/j.1523-1755.1998.00084.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Human recombinant erythropoietin (EPO) requirements in the group of patients with tumor necrosis factor-α (TNF-α) < 2 and interleukin-6 (IL-6) production < 40 (N = 11; ) versus the group of patients with TNF-α ≥ 2ng/ml and IL-6 production ≥ 40ng/ml (N = 14; ▪). Kidney International 1998 54, 1337-1343DOI: (10.1046/j.1523-1755.1998.00084.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Relationship between interleukin-6 (IL-6) production by peripheral blood mononuclear cells (PBMC) and erythropoietin (EPO) requirements in 34 hemodialysis subjects (r = 0.384, P = 0.039). Kidney International 1998 54, 1337-1343DOI: (10.1046/j.1523-1755.1998.00084.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Relationship between tumor necrosis factor-α (TNF-α) production by peripheral blood mononuclear cells (PBMC) and erythropoietin (EPO) requirements in 34 hemodialysis subjects (r = 0.379, P = 0.02). Kidney International 1998 54, 1337-1343DOI: (10.1046/j.1523-1755.1998.00084.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Relationship between interleukin (IL)-12 production by peripheral blood mononuclear cells (PBMC) and erythropoietin (EPO) requirements in 34 hemodialysis subjects (r = 0.378, P = 0.029). Kidney International 1998 54, 1337-1343DOI: (10.1046/j.1523-1755.1998.00084.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 6 Schematic view of the network of cytokines interactions involved in the deranged regulation of the hemopoiesis. The positive or negative regulations are indicated in the balloons. Data from17,18,26-28 plus the results of our study were combined to draw the cartoon. Kidney International 1998 54, 1337-1343DOI: (10.1046/j.1523-1755.1998.00084.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1337-1343DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1337-1343DOI: (10.1046/j.1523-1755.1998.00084.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1337-1343DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1337-1343DOI: (10.1046/j.1523-1755.1998.00084.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1337-1343DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1337-1343DOI: (10.1046/j.1523-1755.1998.00084.x) Copyright © 1998 International Society of Nephrology Terms and Conditions