Nanoparticulate Cancer-Starvation Therapy

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Presentation transcript:

Nanoparticulate Cancer-Starvation Therapy Shutao Guo, Daniel S. Kohane Chem Volume 2, Issue 2, Pages 168-170 (February 2017) DOI: 10.1016/j.chempr.2017.01.014 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Diagram of Mg2Si NPs Serving as an Intratumoral Deoxygenation Agent for Specific Cancer-Starvation Therapy Activated by the acidic tumor microenvironment, the Mg2Si NPs generate reactive silane, producing local hypoxia and SiO2 aggregates to block tumor blood capillaries and subsequently prevent reoxygenation. The deoxygenated tumor with no further oxygen supply will suffocate. Reproduced with permission from Macmillan Publishers Ltd: Nature Nanotechnology (Shi et al.4), copyright 2017. Chem 2017 2, 168-170DOI: (10.1016/j.chempr.2017.01.014) Copyright © 2017 Elsevier Inc. Terms and Conditions