MYD88 Somatic Mutation Is a Diagnostic Criterion in Primary Cutaneous Large B- Cell Lymphoma Sarah Menguy, Audrey Gros, Anne Pham-Ledard, Maxime Battistella,

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MYD88 Somatic Mutation Is a Diagnostic Criterion in Primary Cutaneous Large B- Cell Lymphoma Sarah Menguy, Audrey Gros, Anne Pham-Ledard, Maxime Battistella, Nicolas Ortonne, François Comoz, Brigitte Balme, Vanessa Szablewski, Laurence Lamant, Agnès Carlotti, Marie-Hélène Lorton, Anne de Muret, François Le Gall, Frédéric Franck, Anne Croue, David Cappellen, Marie Beylot-Barry, Jean-Philippe Merlio, Béatrice Vergier Journal of Investigative Dermatology Volume 136, Issue 8, Pages 1741-1744 (August 2016) DOI: 10.1016/j.jid.2016.04.018 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Two examples of primary cutaneous large B-cell lymphoma subtypes included in this study. Left panel, primary cutaneous follicle center lymphoma with large-cell morphology. (a) Diffuse infiltration of the dermis by lymphomatous cells (HE&S, original magnification ×100. (b) Large tumor cells with centroblastic morphology and small nucleoli (HE&S, original magnification ×400). (c) Negative Bcl-2 immunostaining result (original magnification ×400). (d) Negative MUM1 immunostaining result (original magnification ×400). Right panel, primary cutaneous large B-cell lymphoma-leg type. (e) Diffuse infiltration of the dermis by lymphomatous cells (HE&S, original magnification ×100). (f) Large tumor cells with immunoblastic morphology and prominent nucleolus (HE&S, original magnification ×400). (g) Strong Bcl-2 immunostaining result (original magnification ×400). (h) Positive of MUM1 immunostaining result (original magnification ×400). Scale bars for a and e = 0.5 mm. Scale bars for b, c, d, f, g and h = 0.05 mm. HE&S, hematoxylin, eosin and safranin staining. Journal of Investigative Dermatology 2016 136, 1741-1744DOI: (10.1016/j.jid.2016.04.018) Copyright © 2016 The Authors Terms and Conditions