Alyson A. Lokken, Nancy J. Zeleznik-Le Cancer Cell

Slides:

Advertisements

Similar presentations

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Advertisements

Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia Bin Zhang, Yin Wei Ho, Qin Huang, Takahiro Maeda,

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib Ling Li, Lisheng Wang, Liang Li, Zhiqiang.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells David J. Wong, Helen Liu, Todd W. Ridky, David Cassarino, Eran Segal, Howard.

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.

Cancer: Inappropriate Expression of Stem Cell Programs?

Dysfunctional Niches as a Root of Hematopoietic Malignancy

NF-κB: A Coordinator for Epigenetic Regulation by MLL

Genomic Dark Matter Sheds Light on EVI1-Driven Leukemia

Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

Metastasis gets site specific

Mutant p53 gain of function: The NF-Y connection

Volume 11, Issue 4, Pages (April 2007)

Bernd B. Zeisig, Ngai Cheung, Jenny Yeung, Chi Wai Eric So Cancer Cell

Michael W.M. Kühn, Scott A. Armstrong Cancer Cell

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

Andrew G. Muntean, Jay L. Hess Cancer Cell

CALming Down T Cell Acute Leukemia

When Deletions Gain Functions: Commandeering Epigenetic Mechanisms

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Michael W.M. Kühn, Scott A. Armstrong Cancer Cell

DAISY: Picking Synthetic Lethals from Cancer Genomes

Volume 26, Issue 1, Pages 1-2 (July 2014)

T.S. Karin Eisinger-Mathason, M. Celeste Simon Cancer Cell

The Wind God Promotes Lung Cancer

Regulating Cancer Stem Cells the miR Way

IDH1, Histone Methylation, and So Forth

Can Treating the SYK Cell Cure Leukemia?

CALming Down T Cell Acute Leukemia

Compacting Chromatin to Ensure Muscle Satellite Cell Quiescence

Dysfunctional Niches as a Root of Hematopoietic Malignancy

Combinatorial Haplo-Deficient Tumor Suppression in 7q-Deficient Myelodysplastic Syndrome and Acute Myeloid Leukemia Britta Will, Ulrich Steidl Cancer.

Coordinate Transcriptional Regulation by ERG and Androgen Receptor in Fusion- Positive Prostate Cancers Yu Chen, Charles L. Sawyers Cancer Cell Volume.

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

A Histone Modifier’s Ill-Gotten Copy Gains

MicroRNAs and Parallel Stem Cell Lives

The p27Kip1 tumor suppressor gene: Still a suspect or proven guilty?

Volume 20, Issue 1, Pages 3-5 (July 2011)

A MENage à Trois in Leukemia

A New Therapeutic Target for Leukemia Comes to the Surface

Glimpses of the Epigenetic Landscape

FAL1ing inside an Amplicon

Considering the critical interface between tumor cells and stromal cells in the search for targets for anticancer therapy Laurence Blavier, Yves A. DeClerck

Meddling with METTLs in Normal and Leukemia Stem Cells

A New FOXO Pathway Required for Leukemogenesis

On the Origin of Leukemic Species

Xin Huang, Jianlong Wang Molecular Cell

aSIRTing Control over Cancer Stem Cells

John D. Gordan, Craig B. Thompson, M. Celeste Simon Cancer Cell

Volume 14, Issue 4, Pages (October 2008)

Genome-Wide SNP Analysis in Cancer: Leukemia Shows the Way

John D. Crispino, Michelle M. Le Beau Cancer Cell

TFIID and MYB Share a Therapeutic Handshake in AML

FAL1ing inside an Amplicon

Volume 10, Issue 3, Pages (September 2006)

Attacking Cancer at Its Root

Searching for leukemia stem cells—Not yet the end of the road?

Is Cyclin D1-CDK4 kinase a bona fide cancer target?

Volume 13, Issue 4, Pages (April 2008)

Mind the IQGAP Cancer Cell

Volume 12, Issue 6, Pages (December 2007)

Anthony N. Imbalzano, Stephen N. Jones Cancer Cell

Cellular Alchemy and the Golden Age of Reprogramming

Kevin Huang, Guoping Fan Cell Stem Cell

Presentation transcript:

Breaking the LSD1/KDM1A Addiction: Therapeutic Targeting of the Epigenetic Modifier in AML Alyson A. Lokken, Nancy J. Zeleznik-Le Cancer Cell Volume 21, Issue 4, Pages 451-453 (April 2012) DOI: 10.1016/j.ccr.2012.03.027 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 KDM1A/LSD1 Maintains a Balance in Gene Expression through Activating and Repressive Mechanisms that Are Disrupted in Acute Myeloid Leukemia (A and B) In normal cells, KDM1A activates or represses genes through its histone demethylase activity (A), maintaining the balance between hematopoietic stem cells and differentiation to mature myeloid cells (B). (C) In AML, increased KDM1A expression promotes an oncogenic gene expression program, causing a block in differentiation associated with increased H3K4me3 to H3K4me2 ratio at the promoter of target genes. Inhibition of KDM1A restores this balance, promoting blast cell differentiation. Cancer Cell 2012 21, 451-453DOI: (10.1016/j.ccr.2012.03.027) Copyright © 2012 Elsevier Inc. Terms and Conditions