A pilot study of regional perfusion and oxygenation in calf muscles of individuals with diabetes with a noninvasive measure Jie Zheng, PhD, Mary K. Hasting,

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Presentation transcript:

A pilot study of regional perfusion and oxygenation in calf muscles of individuals with diabetes with a noninvasive measure Jie Zheng, PhD, Mary K. Hasting, PT, DPT, MSCI, Xiaodong Zhang, PhD, Andrew Coggan, PhD, Hongyu An, PhD, Darrah Snozek, BS, John Curci, MD, Michael J. Mueller, PT, PhD Journal of Vascular Surgery Volume 59, Issue 2, Pages 419-426 (February 2014) DOI: 10.1016/j.jvs.2013.07.115 Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 1 Examples of skeletal muscle blood flow (SMBF) maps, at rest and during isometric contraction, from a healthy volunteer (A and B) and an age-matched diabetes mellitus (DM) patient (C and D). The yellow and red regions of interest in the SMBF map of (A) indicate the soleus and gastrocnemius muscle regions, respectively. Reduced SMBF in DM from the contraction can be easily seen in the subtracted map (D), compared with the map of a healthy volunteer in (B). Color bar range, 0 to 150 mL/100 g/min. Journal of Vascular Surgery 2014 59, 419-426DOI: (10.1016/j.jvs.2013.07.115) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 2 Skeletal muscle oxygen extraction fraction (SMOEF) maps, at rest and during isometric contraction, from the same subjects in Fig 1: a healthy volunteer (A) and an age-matched diabetes mellitus (DM) patient (B). Elevated SMOEF in a healthy volunteer during the contraction can be observed. In contrast, the SMOEF map of contraction in DM patient shows similar intensity as the map of rest. Color bar range, 0.1 to 0.8. Journal of Vascular Surgery 2014 59, 419-426DOI: (10.1016/j.jvs.2013.07.115) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 3 Relationships of exercise skeletal muscle blood flow (SMBF) and skeletal muscle oxygen consumption rate (SMVO2) with HbA1c in patients with diabetes mellitus (DM). The fast-twitch gastrocnemius muscle shows more decreased values with increased HbA1c than the slow-twitch soleus muscle during the isometric contraction. The exercise SMBF is less sensitive to the changes in HbA1c than the exercise SMVO2. The empirical exponential fitting curves are used to show the trend of the data. Journal of Vascular Surgery 2014 59, 419-426DOI: (10.1016/j.jvs.2013.07.115) Copyright © 2014 Society for Vascular Surgery Terms and Conditions