Volume 139, Issue 6, Pages 1942-1951.e2 (December 2010) Loci From a Genome-Wide Analysis of Bilirubin Levels Are Associated With Gallstone Risk and Composition  Stephan Buch, Clemens Schafmayer, Henry Völzke, Marcus Seeger, Juan F. Miquel, Silvia C. Sookoian, Jan H. Egberts, Alexander Arlt, Carlos J. Pirola, Markus M. Lerch, Ulrich John, Andre Franke, Oliver von Kampen, Mario Brosch, Michael Nothnagel, Wolfgang Kratzer, Bernhard O. Boehm, Dieter C. Bröring, Stefan Schreiber, Michael Krawczak, Jochen Hampe  Gastroenterology  Volume 139, Issue 6, Pages 1942-1951.e2 (December 2010) DOI: 10.1053/j.gastro.2010.09.003 Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1 Overview of the physical and genetic structure of the LST-3TM12-SLCO1B-SLCO1A2 gene region on chromosome 12. The physical position of the investigated single nucleotide polymorphisms and a schematic illustration of the gene structure are shown in the top panel. The coordinates refer to the NCBI genome assembly build 36. The middle panel gives an overview of the linkage disequilibrium structure of the locus (D′) as generated by the University of California at Santa Cruz (UCSC) Genome Browser from the HapMap data (The International HapMap Consortium; www.hapmap.org). The lower panel shows the respective physical distances and r2 values between the investigated SNP markers in the 3 genes of interest as calculated by Haploview (Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263–265). Gastroenterology 2010 139, 1942-1951.e2DOI: (10.1053/j.gastro.2010.09.003) Copyright © 2010 AGA Institute Terms and Conditions