The Natural History of Corticosteroid Therapy for Ulcerative Colitis in Children  Jeffrey Hyams, James Markowitz, Trudy Lerer, Anne Griffiths, David Mack, Athos Bousvaros, Anthony Otley, Jonathan Evans, Mariann Pfefferkorn, Joel Rosh, Robert Rothbaum, Subra Kugathasan, Adam Mezoff, Robert Wyllie, Vasundhara Tolia, J. Fernando delRosario, M. Susan Moyer, Maria Oliva–Hemker, Neal LeLeiko  Clinical Gastroenterology and Hepatology  Volume 4, Issue 9, Pages 1118-1123 (September 2006) DOI: 10.1016/j.cgh.2006.04.008 Copyright © 2006 American Gastroenterological Association Terms and Conditions

Figure 1 Short-term clinical response (change in PGA) after early (<30 days of diagnosis) corticosteroid therapy. CS, corticosteroids; PGA, physician global assessment. Clinical Gastroenterology and Hepatology 2006 4, 1118-1123DOI: (10.1016/j.cgh.2006.04.008) Copyright © 2006 American Gastroenterological Association Terms and Conditions

Figure 2 One-year outcome of UC patients treated with CS therapy within 30 days of diagnosis. CS, corticosteroids. *One patient had colectomy within 3 months of diagnosis; 2 patients had colectomy within 3–6 months of diagnosis. Clinical Gastroenterology and Hepatology 2006 4, 1118-1123DOI: (10.1016/j.cgh.2006.04.008) Copyright © 2006 American Gastroenterological Association Terms and Conditions

Figure 3 Cumulative probability of colectomy at quarterly intervals for children with UC in the first year after diagnosis. ■, All UC patients (n = 97); •, UC patients who received corticosteroid therapy (n = 77). Clinical Gastroenterology and Hepatology 2006 4, 1118-1123DOI: (10.1016/j.cgh.2006.04.008) Copyright © 2006 American Gastroenterological Association Terms and Conditions

Figure 4 Percent of UC patients receiving early CS therapy who received CS or other selected therapies in follow-up periods. CS, corticosteroids. *Excludes patients with colectomy. ○, CS; ■, mesalamine; ▴, immunomodulators; , infliximab; x, cyclosporine/tacrolimus. Clinical Gastroenterology and Hepatology 2006 4, 1118-1123DOI: (10.1016/j.cgh.2006.04.008) Copyright © 2006 American Gastroenterological Association Terms and Conditions