Macrophage Metabolism Shapes Angiogenesis in Tumors

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Macrophage Metabolism Shapes Angiogenesis in Tumors Alberto Mantovani, Massimo Locati Cell Metabolism Volume 24, Issue 5, Pages 653-654 (November 2016) DOI: 10.1016/j.cmet.2016.10.016 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Impact of REDD1/mTOR-Mediated Control of Glycolysis in TAMs on Tumor Angiogenesis and Metastasization (A) Hypoxia-induced REDD1 suppresses mTOR activity and inhibits glycolysis in TAMs, which leaves more glucose available for the endothelial cells. This results in the formation of a leaky vascular network that promotes metastasis. (B) Targeting REDD1 in TAMs installs glucose competition and reduces endothelial glucose uptake, resulting in normalized blood vessel formation and reduced metastasis. Cell Metabolism 2016 24, 653-654DOI: (10.1016/j.cmet.2016.10.016) Copyright © 2016 Elsevier Inc. Terms and Conditions