The Role of Missing Killer Cell Immunoglobulin-Like Receptor Ligands in T Cell Replete Peripheral Blood Stem Cell Transplantation from HLA-Identical Siblings

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Presentation transcript:

The Role of Missing Killer Cell Immunoglobulin-Like Receptor Ligands in T Cell Replete Peripheral Blood Stem Cell Transplantation from HLA-Identical Siblings Johannes Clausen, Brigitte Kircher, Jutta Auberger, Petra Schumacher, Hanno Ulmer, Gabriele Hetzenauer, Dominik Wolf, Günther Gastl, David Nachbaur Biology of Blood and Marrow Transplantation Volume 16, Issue 2, Pages 273-280 (February 2010) DOI: 10.1016/j.bbmt.2009.10.021 Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 OS (A) and RFS (B) stratified by HLA-C KIR ligand group (n = 100). Biology of Blood and Marrow Transplantation 2010 16, 273-280DOI: (10.1016/j.bbmt.2009.10.021) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Cumulative incidence of relapse (A) and aGVHD grade II-IV (B), stratified by HLA-C KIR ligand group (n = 100). Biology of Blood and Marrow Transplantation 2010 16, 273-280DOI: (10.1016/j.bbmt.2009.10.021) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 (A) RFS in HLA-A3 or -A11positive patients, stratified by donor KIR2DS5 expression (n = 34). (B) Cumulative incidence of relapse in HLA-A3 or -A11positive patients, stratified by donor KIR2DS5 expression (n = 34). (C) Cumulative incidence of aGVHD grade II-IV, stratified by HLA-A3 or HLA-A11 positivity (n = 100). Biology of Blood and Marrow Transplantation 2010 16, 273-280DOI: (10.1016/j.bbmt.2009.10.021) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions