Personalizing Therapy for Colorectal Cancer

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Presentation transcript:

Personalizing Therapy for Colorectal Cancer Ashley Wong, Brigette B.Y. Ma Clinical Gastroenterology and Hepatology Volume 12, Issue 1, Pages 139-144 (January 2014) DOI: 10.1016/j.cgh.2013.08.040 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Selected signaling pathways of clinical significance in CRC and therapeutic targets. Schematic diagram of approved targeted agents for treatment of advanced CRC and their mode of action in a CRC cell. AKT, protein kinase B; BAD, Bcl-2-associated death promoter; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; NFκB, nuclear factor κ-light-chain-enhancer of activated B cells; PIGF, phosphatidylinositol-glycan biosynthesis class F protein. Clinical Gastroenterology and Hepatology 2014 12, 139-144DOI: (10.1016/j.cgh.2013.08.040) Copyright © 2014 AGA Institute Terms and Conditions