Brian Kornblit, Tania Masmas, Søren L. Petersen, Hans O

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Association of HMGB1 Polymorphisms with Outcome after Allogeneic Hematopoietic Cell Transplantation Brian Kornblit, Tania Masmas, Søren L. Petersen, Hans O. Madsen, Carsten Heilmann, Lone Schejbel, Henrik Sengeløv, Klaus Müller, Peter Garred, Lars Vindeløv Biology of Blood and Marrow Transplantation Volume 16, Issue 2, Pages 239-252 (February 2010) DOI: 10.1016/j.bbmt.2009.10.002 Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Schematic illustration of the high mobility group box 1 protein gene locus with exon I to V, marked as solid boxes, and the approximate location of the genetic variants. The most common inferred haplotypes (frequency >3%), called H1 to H4, in patients and donors are shown. Modified from Ferrari et al. [37]. Biology of Blood and Marrow Transplantation 2010 16, 239-252DOI: (10.1016/j.bbmt.2009.10.002) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Cumulative incidence of relapse incidence and relapse related mortality according to patient −1377delA genotype in the transplantation cohort treated with myeloablative conditioning. Gray's k-test between patients with A/A genotype versus patients with A/− or −/− genotypes. Biology of Blood and Marrow Transplantation 2010 16, 239-252DOI: (10.1016/j.bbmt.2009.10.002) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Cumulative incidence of OS, PFS, RI, and RRM according to patient 3814C > G genotype in the transplantation cohort treated with myeloablative conditioning. Gray's k-test between patients with G/G genotype versus patients with C/G or C/C genotype. Biology of Blood and Marrow Transplantation 2010 16, 239-252DOI: (10.1016/j.bbmt.2009.10.002) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Cumulative incidence of limited or extensive cGVHD, according to donor 2351insT genotype in the transplantation cohort treated with myeloablative conditioning. Biology of Blood and Marrow Transplantation 2010 16, 239-252DOI: (10.1016/j.bbmt.2009.10.002) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions