DNA, protein synthesis, gene expression & mutations

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DNA, protein synthesis, gene expression & mutations Our good looks! DNA, protein synthesis, gene expression & mutations

Assume these are all from the same person: what do these different cell types have in common?

If all cells have the same DNA, how are different cells different? Result of control of gene expression

Different Genes – Different Functions Pancreas Cell Bone Cell Brain Cell

Types of regulatory proteins activator proteins: repressor proteins:

Additional means of regulating gene expression

To complicate matters . . . The environment can play a role in gene expression

What’s a mutation?

Types of mutations Base substitutions Base insertions or deletions Chromosomal aberrations

Base substitutions May have no effect due to May have big effect

Base substitution

Base insertions or deletions The addition or removal of one or more bases

Base deletion

Chromosomal aberrations Changes to the overall organization of genes on a chromosome

Causes of mutations spontaneous mutagens

Mutation summary 1.