DNA, protein synthesis, gene expression & mutations Our good looks! DNA, protein synthesis, gene expression & mutations
Assume these are all from the same person: what do these different cell types have in common?
If all cells have the same DNA, how are different cells different? Result of control of gene expression
Different Genes – Different Functions Pancreas Cell Bone Cell Brain Cell
Types of regulatory proteins activator proteins: repressor proteins:
Additional means of regulating gene expression
To complicate matters . . . The environment can play a role in gene expression
What’s a mutation?
Types of mutations Base substitutions Base insertions or deletions Chromosomal aberrations
Base substitutions May have no effect due to May have big effect
Base substitution
Base insertions or deletions The addition or removal of one or more bases
Base deletion
Chromosomal aberrations Changes to the overall organization of genes on a chromosome
Causes of mutations spontaneous mutagens
Mutation summary 1.