Epithelioid Granulomas Associate With Increased Severity and Progression of Crohn’s Disease, Based on 6-Year Follow-Up  Christopher M. Johnson, Douglas J. Hartman, Claudia Ramos-Rivers, Bhavana Bhagya Rao, Abhik Bhattacharya, Miguel Regueiro, Marc Schwartz, Jason Swoger, Jana Al Hashash, Arthur Barrie, Timothy P. Pfanner, Michael Dunn, Ioannis E. Koutroubakis, David G. Binion  Clinical Gastroenterology and Hepatology  Volume 16, Issue 6, Pages 900-907.e1 (June 2018) DOI: 10.1016/j.cgh.2017.12.034 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 Montreal Classification and delta Lémann Index. (A) Disease location. L1, ileal; L2, colonic; L3, ileocolonic; L4, upper tract. (B) Disease behavior. B1, nonstricturing and nonpenetrating; B2, stricturing; B3, penetrating or perforating. (C) Comparison of granuloma rates in patients according to Lémann Index disease trajectory. Improving, DLI <0; stable, DLI = 0; worsening, DLI >0. *P < .05, ∗∗∗P < .001; NS, not significant. Clinical Gastroenterology and Hepatology 2018 16, 900-907.e1DOI: (10.1016/j.cgh.2017.12.034) Copyright © 2018 AGA Institute Terms and Conditions

Figure 2 Granuloma rates in surgical patients according to anti-TNF exposure. Rates of granuloma in surgical patients noted in surgical specimens stratified by anti-TNF exposure at the time of surgery. *P < .05; NS, not significant. Clinical Gastroenterology and Hepatology 2018 16, 900-907.e1DOI: (10.1016/j.cgh.2017.12.034) Copyright © 2018 AGA Institute Terms and Conditions

Figure 3 Repeat surgical-free survival analysis. Cumulative probability of repeat surgical resection according to granuloma status. The x-axis is years after first surgical resection. Clinical Gastroenterology and Hepatology 2018 16, 900-907.e1DOI: (10.1016/j.cgh.2017.12.034) Copyright © 2018 AGA Institute Terms and Conditions